Combinatorial joining

Hinds-Frey, K.R., Nishikata, H., Litman, R.T., Litman, G.W. (1993). Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity. J. Exp. Med. 178, 815-824. 

The wide variety of immunoglobulins required for a full immune response in humans and mice results from the combinatorial joining of immunoglobulin gene (Ig) V, D, and J gene segments from class switch recombination and from somatic hypermutation of variable (V) regions (see Chapter 11). Several polymerases have been implicated in the DNA synthesis required for development of a normal immune system. 

If we consider the seven components in tables 5.12 and 5.13 as representative of the chemistry of natural olivines, it is clear that 21 regular binary interaction parameters (disregarding ternary and higher-order terms) are necessary to describe their mixing properties, through a combinatory approach of the Wohl or Kohler type (cf section 3.10). In reality, the binary joins for which interactions have been sufficiently well characterized are much fewer. They are briefly described below. 

Dr. Miguel Quimpere joined BioChem Therapeutic in 1990 as a synthetic organic chemist and has since moved on to data management and molecular modeling, with a particular view to diverse library design and combinatorial chemistry. 

Combinatorial chemistry and combmatonal technologies fall into a new interdisciplinary field joining combmatonal informatics with automated synthesis of chemical "libranes" followed by automated screening, with the mam output m medicinal chemistry and drug discovery This nascent technology has produced more new compounds in just a few years than the pharmaceutical industry did m its entire previous history... 

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