Combinatorial chemistry handles

Key Words Acidolytic cleavage backbone amide linkage bioconjugate chemical ligation combinatorial chemistry handle linker peptide alcohol peptide aldehyde peptide ester peptide thioester protecting group solid support. 

In addition, further automation will be needed in what is still very much a hands-on art. Autoinjectors coupled to complete analytical data systems and readers for 96-well plates are the beginning of what will continue to be a necessary trend of residue chemistry. The application of the techniques of combinatorial chemistry/biochemistry, which has produced screening methodology for handling many variables, might be appropriate to residue chemistry. 

Combinatorial chemistry and HT E are powerful tools in the hands of a scient ist, as they are a source for meaningful consistent records of data that would be hard to obtain via conventional methods within a decent timeframe. This blessing of fast data acquisition can turn into a curse if the experimentalist does not take precautions to carefully plan the experiments ahead and the means of handling the data and analyzing them afterwards. The two essential elements that ensure a successful execution of ambitious projects on a rational and efficient basis are, therefore, tools that enable the scientist to carefully plan experiments and get the most out of the minimum number of experiments in combination with the possibility of fast and reliable data retrieval from databases. Therefore, experimental planning and data management are complementary skillsets for the pre- and post experimental stages. 

As a large number of chemical entities is involved in combinatorial chemistry, manual handling is either very tedious or simply not possible therefore, the tags should be readable by technical devices. Furthermore, for the efficient characterization of compound libraries, it is much more efficient to encode the planned structures before the synthesis than afterwards. The latter would require extensive analysis of the products using advanced techniques, and this again is either extremely tedious or impossible. 

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