Combinatorial approaches, to design

Combinatorial Approaches to Design Complex Metal Oxides... 

Includes a chapter on combinatorial approaches to design compiex metal oxides... 

Muller, A., Drese, K., Gnaser, H., Hampe, M., Hessel, V, Lowe, H., Schmitt, S., Zapf, R., A combinatorial approach to the design of a screening reactor for parallel gas phase catalyst screening, Chim. Oggi 21, 9 (2003)... 

CombiDock Tweaks the DOCK algorithm to identify suitable scaffold orientations in the binding pocket. Proceeds using the seed and grow approach to design combinatorial libraries (73)... 

Liu, D., Jiang, H., Chen, K. and Ji, R. A New Approach to Design Virtual Combinatorial Library with Genetic Algorithm Based on 3D Grid Property. J. Chem. Inf. Comput. Sci., 1998, 38, 233-242. 

Murer, P., Lewandowslci, K., Svec, F., Frechet, J. M. On-bead combinatorial approach to the design of chiral stationary phases for HPLC, Anal. Chem., 1999, 71, 1278-1284. 

A complete chapter is devoted to novel combinatorial approaches to highly selective chemoreceptors designed for parallel analysis by sensor devices. An assay-oriented chapter on peptide libraries in T-cell-mediated immune response illustrates how libraries of extreme complexity (1013) can lead directly to single molecules with activities that may be... 

The chapter begins with a discussion of similarity and diversity measures and how they can be applied in a virtual screening context. The various computational filters in use are also discussed. The rest of the chapter is concerned with different approaches to combinatorial library design, beginning with reagent-based methods followed by product-based approaches of cherry picking and combinatorial subset selection. Finally, approaches to designing libraries optimized on multiple properties simultaneously are discussed. 

Kurochkina VB, Nys PS (2002) Kinetic and thermodynamic approach to design of processes for enzymatic synthesis of betalactams. Biocatal Biotransform 20(1) 35-41 Lee SB, Ryu DDY (1982) Reaction kinetics and mechanism of penicillin amidase a comparative study of computer simulation. Enzyme Microb Technol 4 35-38 Lin WJ, Kuo BY, Chou CP (2001) A biochemical engineering approach for enhancing production of recombinant penicillin acylase in Escherichia coli. Bioproc Biosys Eng 24 239-247 Lindsay JP, Clark DS, Dordick JS (2004) Combinatorial formulation of biocatalyst preparation for increased activity in organic solvents salt activation of penidllin amidase. Biotechnol Bioeng 85(5) 553-560... 

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