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Colon-specific delivery strategies

The same strategy was applied in colon-specific delivery of two corticosteroids used to treat inflammatory bowel disease [20][21], Indeed, budeso-nide /3-D-glucuronide and dexamethasone /3-D-glucuronide underwent ready hydrolysis in the luminal contents of rat colon and caecum. Rat mucosal homogenates were less active, and hydrolysis in human fecal samples was quite low. Based on these and other studies, the prodrugs were found to be suitable candidates for delivery of corticosteroids to the large intestine. [Pg.684]

Numerous strategies have been developed to achieve colon-specific drag delivery. Some approaches, such as the use of sustained release formulations, enteric-coated dosage forms and osmotic pumps, were not... [Pg.161]

Currently, four strategies are being pursued to achieve colon-specific drug delivery. ... [Pg.1254]

Delivery vehicle Several TE strategies involve the use of biomaterials as reservoirs for controlled drug dehvery of bioactive molecules. These molecules can act as chemoattractants that foster ceU colonization of the scaffold as well as promote stem cell differentiation toward a specific hneage. The choice of the biomaterial and its fabrication process should not have a detrimental effect on drug availability and bioactivity. ... [Pg.182]

See other pages where Colon-specific delivery strategies is mentioned: [Pg.162]    [Pg.1255]    [Pg.1381]    [Pg.1484]    [Pg.2030]    [Pg.176]    [Pg.39]    [Pg.45]    [Pg.157]    [Pg.148]    [Pg.1232]    [Pg.2713]    [Pg.8]    [Pg.641]    [Pg.253]    [Pg.253]    [Pg.252]    [Pg.557]    [Pg.120]    [Pg.474]   
See also in sourсe #XX -- [ Pg.335 , Pg.336 , Pg.336 ]



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