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Collapsin response mediator proteins CRMPs

Two effects relevant to the mechanism of action of lacosamide as an antiseizure drug have been described. Lacosamide enhances slow inactivation of voltage-gated Na+ channels. It also binds to the collapsin-response mediator protein, CRMP-2, thereby blocking the effect of neurotrophic factors such as BDNF and NT3 on axonal and dendritic growth. [Pg.520]

Charrier E, Reibel S, Rogemond V, Aguera M, Thomasset N, Honnorat J. Collapsin response mediator proteins (CRMPs) Involvement in nervous system development and adult neurodegenerative disorders. Mol Neurobiol 2003 28(l) 51-64. [Pg.173]

Collapsin response mediator proteins (CRMPs) include a family of hve members that are involved in... [Pg.325]

Weidemann W, Stelzl U, Lisewski U et al. (2006) The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNB), the key enzyme of sialic acid biosynthesis. FEBS Lett 580, 6649-6654. [Pg.189]

See other pages where Collapsin response mediator proteins CRMPs is mentioned: [Pg.149]    [Pg.415]    [Pg.220]    [Pg.149]    [Pg.415]    [Pg.220]    [Pg.510]    [Pg.253]    [Pg.343]    [Pg.350]   


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Collapsin response mediator protein

Collapsin response mediator protein CRMP)

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