Collagen immune complexes

The inducers of these alterations range from certain proteolytic enzymes, in particular thrombin, to large molecules such as collagen, immune complexes, zymosan (alpha 41) and cationic polymers (alpha 28), and, finally, low molecular weight compounds such as adenosine-5-diphosphate (ADP), adrenaline, vasopressin, and serotonin. This wide variety of materials, all of them capable of eliciting the same result, suggests that.upon quite different stimuli of the plasma membrane, the same sequence of events is triggered off. These events can be subdivided by several criteria in different phases ... 

IgA-R Fc-R (immune complexes, opsonized material) Matrix compounds (hyaluronan, fibronectin, denatured collagens, PEHNP) Uroplasminogen-R... 

Jansen, J.M., Schutte, A.J.H., I.D. Elema, I.D. etal. (1984). Local immune complexes and inflammatory response in patients with chronic interstitial pulmonary disorders associated with collagen vascular diseases. Clin. Exp. Immunol. 56, 311-320. 

B28. Brownlee, M., Pongor, S., and Cerami, A., Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen Role in the in situ formation of immune complexes. J. Exp. Med. 158, 1739-1744 (1983). 

Mechanism of Action A heavy metal antagonist that chelates copper, iron, mercury, lead to form complexes, promoting excretion of copper. Combines with cystine-forming complex, thus reducing concentration of cystine to below levels for formation of cystine stones. Exact mechanism for rheumatoid arthritis is unknown. May decrease cell-mediated immune response. May inhibit collagen formation. Therapeutic Effect Promotes excretion of copper, prevents renal calculi, dissolves existing stones, acts as anti-inflammatory drug. 

In rheumatoid arthritis, a chronic inflammation of joints, the serum and joint fluids contain abnormal complexes, which appear to consist entirely of immunoglobulins. They may be antibody - antiidiotype antibody complexes.Immunization of animals with type II collagen induces a very similar arthri-tis,496,497 collagen probably doesn t supply the... 

The diverse class of polypeptides allows for the realization of, on the one hand, high-performance construction materials, such as dragline spider silk, microtubules, or collagen fibers. On the other hand, (multi)functional molecules or molecular assemblies can be found, for example, necessary for biocatalysis (enzymes) or for the function of the immune system (immune globulins). Moreover, proteins participate in the storage and the directed transport of materials in biological systems and are essential components for the communication in complex biosystems in form of, for example, cell-surface markers, receptors, regulators, or hormones. 

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