Polymer collagen-based

Cultured Skin Substitutes (Univ. Cincinnati/Shriners Hospitals Collagen-based polymer with autologous fibroblasts Autologous keratinocytes Bum wounds congenital nevi chronic wounds (using allogeneic cells) [25-29]... 

Rao, K.P. Recent developments of collagen-based materials for medical applications and drug delivery systems. J. Biomater. Sci., Polym. Ed. 1995, 7 (7), 623-645. 

Xiangmei W, Jing Z, Hao C et al (2009) Preparation and characterization of collagen-based composite conduit for peripheral nerve regeneration. J Appl Polymer Sci 112 3652-3662... 

Egyptians sutured wounds as early as 3500 b.c. using a variety of natural polymers including treated intestines, which are the early versions of collagen-based surgical gut sutures. Synthetic, absorbable polyesters based on... 

Achilli M, Mantovani D (2010) Tailoring mechanical properties of collagen-based scaffolds for vascular tissue engineering the effects of pH, temperature and ionic strength on gelation. Polymers (Basel) 2 664—680. doi 10.3390/polym2040664... 

Early in our studies it was expected that the post-translational modification of proline hydroxylation, so important to proper collagen structure and function, would raise the value of the temperature, T, for the onset of the inverse temperature transition for models of elastin. Accordingly, hydroxyproline (Hyp) was incorporated by chemical synthesis into the basic repeating sequence to give the protein-based polymers poly[fvs,i(Val-Pro-Gly-Val-Gly), fHyp( al-Hyp-Gly-Val-Gly)], where f sl -i- fnyp = 1 and values of fnyp were 0, 0.01, and 0.1. The effect of prolyl hydroxylation is shown in Figure 7.49. Replacement of proline by hydroxyproline markedly raises the temperature for hydrophobic association. Prolyl hydroxylation moves the movable cusp of... 

Natural collagen-based absorbable sutures have largely been replaced by synthetic absorbable sutures. Synthetic absorbable sutures are made from aliphatic absorbable polyesters and contain one or more of the five basic building blocks glycolide,L-lactide,p-dioxanone, -caprolactone and trimethylene carbonate. With the exception of the trimethylene carbonate building block which results in amorphous polymers, the polymers from the other four blocks are semicrystaUine. 

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