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Alkaloids colchicine

With the completion of Volume VI of this series, a complete structure for colchicine, including stereochemistry, had been established. The [Pg.414]

On the other hand, III, with the double bond unambiguously at position 7a, 12a, has been synthesized and it differs from the authentic degradation product in the IR-fingerprint region (27). However, isomerization of the double bond with boron trifluoride to the 12, 12a position [Pg.417]

Earlier work on the optical rotation behavior of colchicine at the sodium D line was discussed in Volume VI. As rotational data for various derivatives of colchicine accumulated, it became apparent that Leithe s rule, which correlates bases containing aromatic rings stereochemically by optical rotation shifts, is not generally followed in fact, the shifts are often of opposite sign to those found with L-amino acids and L-phenethylamines (28). Several authors (29-31) have pointed out that isoeolchicine and its ring C derivatives have rotation values considerably [Pg.418]

ORD-studies conducted on colchicine derivatives, colchinols, and ]8-and y-lumicolchicine (Table II) have clarified some of the stereochemical aspects of these molecules (28). Colchinol (XIX) and its derivatives are essentially bridged and skewed biphenyls. They show a single strong negative Cotton effect at 260 mp which implies an S-configuration (XX), also indicated in the X-ray analysis of colchicine (XXI). [Pg.419]

Colchicide (XXII) appears to have a single Cotton effect, but two overlapping effects are considered more probable. Hexahydrocolchicine (a cinnamylamine with skewed chromophore) exhibits a strong negative Cotton effect at 250 mp. The j8- and y-lumicolchicines (XXIII) are essentially arylcyclobutenes combined with a, S-unsaturated ketone [Pg.419]


Tulipa edulis Bak. T. gesneriana L. Shan Ci Yu Jin Xian (Tulip) (bulb) Colchicine, alkaloids, starch.48 Relieve swelling, lymphatic gland infection, throat infection. [Pg.166]

No information is currently available on breakdown in soil groundwater or surface water. Colchicine alkaloids withstand storage, drying, and boiling. [Pg.639]

Reviews of this group are available in one of these, coverage is limited to alkaloids elaborated by the Wurmbaeoideae plants. Several new reports concerning exhaustive isolation studies of Colchicum species as well as of Kreysigia multijlora, Merendera fitifolia, and M. jolantae plants have appeared. For the most part, known colchicine alkaloids have been found although structures of several new ones have not been defined. A study of composition of alkaloids in Colchicum luteum at various stages of development has been described. [Pg.457]

E. Colchicine Alkaloids.—A summary of the chemistry and photochemistry of colchicine has appeared as part of an advanced introductory text on alkaloids.176 A survey of plant drugs with cytostatic activity includes a discussion on colchicine.177... [Pg.144]

Tour main groups can be identified I) upper clade alkaloids which affect only neuroreceptors (especially inAChR and nACIiR), 2) upper part of clade 2 between inonocrotaline and colchicine alkaloids which bind to adrenergic and serotonin receptors, 3) lower part of clade 2 between ergoinetrine and berberine alkaloids which affect concomitantly neuroreceptors and DNA and correlated targets and 4) alkaloids which do not affect any of the targets tested (i.e. caffeine and tropine). [Pg.103]

Synthetic approaches to morphine and colchicine alkaloid analogs Wallace, Rebecca Abernathy... [Pg.119]

Most alkaloids are solnble in organic solvents such as chloroform, ether and alcohol, bnt are practically water insoluble. Water-soluble alkaloids include ephedrine and colchicine. Alkaloidal salts are generally solnble in water and alcohol. [Pg.134]

The thioanalogs of natural products such as the steroid (7) or the colchicine alkaloid (8) have also been prepared by use of LR. [Pg.53]


See other pages where Alkaloids colchicine is mentioned: [Pg.125]    [Pg.126]    [Pg.457]    [Pg.527]    [Pg.145]    [Pg.305]    [Pg.139]    [Pg.322]    [Pg.147]    [Pg.316]    [Pg.300]    [Pg.354]    [Pg.407]    [Pg.414]    [Pg.433]    [Pg.28]    [Pg.113]    [Pg.425]    [Pg.468]   
See also in sourсe #XX -- [ Pg.373 ]

See also in sourсe #XX -- [ Pg.425 , Pg.430 ]




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