Cognition deficiencies

Witkin JM, Nelson DL. Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system. Pharmacol Ther 2004 103 1-20. 

Brain cannabinoid receptor. In humans, psychoactive cannabinoids produce euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration, and impairment of memory. The cognitive deficiencies persist after withdrawal. The toxicity of cannabis has been underestimated for a long time, since recent findings revealed that A-9-THG-induced cell death with shrinkage of neurons and DNA fragmentation in the hippocampus. The acute effects of cannabinoids, as well as the development of tolerance, are mediated by G protein-coupled cannabinoid receptors. The CBl receptor and its splice variant, CBl A, are found predominantly in the brain with highest densities in the hippocampus, cerebellum, and striatum. The CB2 receptor is found predominantly in the spleen and in hemopoi-... 

The working hypothesis of cognitive deficits in PD is that they result from impairment of specific cortico-subcortical circuifs. These circuits in part depend on dopamine-linked synapses. Although the original model (see Fig. 1) has been modified, the essential role of dopamine deficiency of the basal ganglia remains at the core of cognitive deficiencies in PD involving the frontal cortices. 

A. The development of multiple cognitive deficiencies manifested by both... 

B. The cognitive deficiencies in Criteria AI and A2 each cause significant impairment in social or occupational functioning and represent a significant decline from a previous level of... 

Elderly people s vitamin B12 deficiency is often associated with cognitive deficiency. According to recent studies by some authors, holoTC is an important marker with which to assess cognitively impaired elderly patients (Valente et al. 2011). In particular, a significant association was found between cobalamin and holoTC levels and the decrease in brain volume lower vitamin concentrations, greater rate of brain volume loss (Smith and Refsum 2009). de Lau et al. (2009) evaluated the association of markers of vitamin B12 status with cerebral white matter lesions, infarcts and cognition the study showed that lack of vitamins... 

Systematic reviews Arsenic enters human food chain possibly by arsenic accumulations in edible plants and crops, from contaminated soils and irrigation water that further reach livestock meat, animal products like milk and egg [9 ]. However in regions like Latin America, despite its long history of arsenic contamination, are rather poorly reported for arsenic toxicity. A systematic review revealed that at least 4.5 million people in Latin America are chronically exposed to high arsenic levels (>50 ng/L) with increased risks of adverse health effects like internal and external cancers, reproductive toxicity and childhood cognitive deficient function [10 ]. 

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