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CNS tissue

Clark G, Stavinoha WB. 1971. A permeability ehange in CNS tissue in chronic poisoning with disulfoton. Life Sci [I] 10 421-423. [Pg.181]

Somewhat surprisingly, microdialysis has also revealed that the time to maximum concentration (T ax) within the CNS is close to the Tj ax value in blood or plasma, irrespective of lipophilicity. For example, the CNS Tj ax for atenolol (log D7 4 = - 1.8) occurs at 2 min in the rat after intravenous administration [8]. In addition the rate of elimination (half-life) of atenolol and other polar agents from the CNS is similar to that in plasma or blood. The implication of these data is that poorly permeable drugs do not take longer to reach equilibrium with CNS tissue than more lipophilic agents... [Pg.51]

Pharmacology Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in CNS tissues. Although the... [Pg.1256]

Lactate <2.1 nunol Acute bacterial, fungal, and tuberculosis meningitis CNS tissue destruction... [Pg.4]

Central nervous tissue appears to provide an especially avid environment for the occurrence of oxygen-radical generation and lipid-peroxidative reactions due to a high content of polyunsaturated fatty acids. There is now considerable biochemical, physiological and pharmacological data that supports such a connection between radical reactions and secondary CNS tissue injury. [Pg.218]

EAE experimental allergic/autoimmune encephalitis is an animal model for demyelinating diseases, such as multiple sclerosis. It is induced by injection of myelin basic protein or whole CNS tissue together with adjuvants. [Pg.774]

See other pages where CNS tissue is mentioned: [Pg.110]    [Pg.26]    [Pg.127]    [Pg.266]    [Pg.1034]    [Pg.354]    [Pg.359]    [Pg.179]    [Pg.10]    [Pg.56]    [Pg.118]    [Pg.7]    [Pg.113]    [Pg.138]    [Pg.17]    [Pg.45]    [Pg.50]    [Pg.293]    [Pg.95]    [Pg.18]    [Pg.69]    [Pg.500]    [Pg.278]    [Pg.750]    [Pg.217]    [Pg.221]    [Pg.221]    [Pg.234]    [Pg.221]    [Pg.546]    [Pg.701]    [Pg.78]    [Pg.83]    [Pg.94]    [Pg.97]    [Pg.124]    [Pg.191]    [Pg.243]    [Pg.304]    [Pg.320]    [Pg.378]    [Pg.380]    [Pg.382]    [Pg.664]    [Pg.18]   
See also in sourсe #XX -- [ Pg.51 ]



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