Cloudy swelling

Renal 4 F (cloudy swelling and narrowing of tubular lumen) ... 

Mendel) (F) Hepatic 0.1 (cloudy swelling of centrilobular cells) Endrin... 

Acute toxic hepatic effects of 1,2-dibromoethane consisting of hepatocellular cloudy swelling, centrilobular fatty change, and patchy necrosis were reported in animals after a single inhalation exposure (Rowe et al. 1952). Repeated inhalation exposures of rats and rabbits to 100 ppm... 

Symptoms of exposure Severe irritation of eyes, skin, and respiratory tract. Contact with skin causes burns. Visual disturbance and cloudy swelling of cornea accompanied by partial or total loss of vision (Patnaik, 1992). 

NS) 5 d/wk 7 hr/d Hepatic 96 158 (increased relative liver weight cloudy swelling or degeneration of parenchyma) ... 

Histopathologic lesions of the liver have been demonstrated in several oral studies in rodents dosed at higher levels of 1,4-dichlorobenzene. Cloudy swelling and centrilobular necrosis were observed in the livers of rats that received 1,4-dichlorobenzene at 500 mg/kg/day for 4 weeks (Hollingsworth et al. 1956). Thirteen-week studies have resulted in degeneration and necrosis of hepatocytes in rats that received doses of 1,200 mg/kg/day and above and in mice, hepatocellular degeneration was observed at... 

Rats died from exposure to 977 ppm for 7 hours but survived when exposed for only 2 hours animals survived exposure to 539ppm for 3 hours but at necropsy showed marked centrilobular necrosis of the liver, as well as cloudy swelling of the tubular epithelium of the... 

The oral LDso in rats has ranged from 0.71 ml/kg to 2.83 g/kg. The effects of intraperi-toneal administration to rats of doses of 100 or 500 mg/kg were assessed at 4 and 24 hours after dosing.In the liver and kidneys, there was qrtoplasmic vacuolization. The high doses caused renal tubular degeneration. In rats fed 0.17g/% for 90 days, effects included cloudy swelling and degeneration of kidney tubules and fatty degeneration of the liver. ... 

Acute exposure of experimental animals resulted in adverse effects similar to those described for humans. Rats did not survive when exposed to the vapor for longer than 6 minutes at 3 000 ppm minimum lethal concentration for an 8-hour exposure was 200ppm these exposures caused hepatic necrosis, pulmonary edema, and cloudy swelling of renal tubules. Depression of the central nervous system (CNS) was observed in rats exposed at higher concentrations, and deaths occurred within 24 hours from respiratory or cardiac... 

NS) Hepatic 310 470 (cloudy swelling) heavy mucous discharge, congestion, hemorrhages, edema)... 

---