Closure Manufacturers Association

The size of CT closures is specified by the nominal outside dimension of the container opening in millimeters, plus a number that represents the style of finish. Both container and closure finishes are standardized so that, at least in theory, a closure of a given size and style should fit any bottle of that same size and style, from any manufacturer. U.S. closure standards have been established by the Closure Manufacturers Association, standards for glass bottles by the Glass Packaging Institute, and for plastic bottles by ASTM International (Fig. 11.8). Common closure diameters are 22-120 mm. 

Batch number (research, pilot, production) and associated manufacturing date For antibiotic drug products, the age of the bulk active drug substance or substances used in manufacturing the batch Analytical data, source of each data point, and date of analysis (e.g., batch, container, composite, etc) pooled estimates may be submitted if individual data points are provided Individual data as well as mean and standard deviation should be reported Tabulated data by storage condition Summary of information on previous formulations during product development this summary may be referenced (if previously submitted) and should include other containers and closures investigated... 

The numerous possible high pressure applications and their associated requirements can be satisfied by a variety of different assemblies of reaction vessels, closures, tubing, valves, pumps or compressors. First, an overview of these different components is presented, after which several complete high-pressure systems found in the literature are discussed. At this point it should be emphasized that in showing equipment from one manufacturer or another, no preference for a particular product is being expressed. Further details on equipment employed for spectroscopy at high pressure are provided in Chapter 3. 

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