Clopidogrel Plavix

The industrial production of CLOPIDOGREL (PLAVIX ) is an interesting example which demonstrates the synthetic potential of non-racemic cyanohydrins (Scheme 5). ... 

Scheme 5 Stereoselective synthesis of Clopidogrel (Plavix ) starting from...

Clopidogrel (Plavix, Hematology Platelet receptor inhibitor... 

Abciximab (ReoPro) Aspirin (Bayer, Ecotrin, St. Joseph s) Clopidogrel (Plavix)... 

The client with arterial occlusive disease is taking clopidogrel (Plavix), an antiplatelet medication. Which statement by the client would warrant intervention by the nurse ... 

The antiplatelet medication clopidogrel (Plavix) to the client with arterial occlusive disease. 

The client has been taking clopidogrel (Plavix) every day. 

The importance of thiophenes in medicinal chemistry can be highlighted by the enormous economic success of thiophene-containing drugs. Pharmaceuticals containing thiophenes such as duloxetine (Cymbalta), olanzapine (Zyprexa), tiotropium (Spiriva), raloxifene (Evista), and zileuton (Zyflo) had combined sales of more than 6 billion in the U.S. in 2010, while the blockbuster drug clopidogrel (Plavix) alone obtained sales in excess of 6 billion in the same year. 

The blockbuster drug, clopidogrel (Plavix), is a thiophene-containing inhibitor of platelet aggregation and is used to treat a variety of conditions caused or aggravated by blood clotting. 

Although the electron-rich thiophene may lead to toxicity, the metabolic chemistry of thiophene can also lead to desirable therapeutic effects as in the case of clopidogrel (Plavix). The parent compound is oxidized by cytochrome P-450, and further oxidation in the presence of water... 

For large or sterically demanding aldehydes, such as a-chlorobenzaldehyde, (R)-HNL mutants possessing a more spacious active site were constructed [1561,1562]. The (R)-o-chloromandelonitrile thus obtained represents the chiral core of the blockbuster clopidogrel (Plavix) (Scheme 2.207). 

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