Mianserin Clonidine

Bertschy G., C. Bryois, G. Bondolfi, A. Velardi, P. Budry, D. Dascal, C. Martinet, D. Baettig, and P. Baumann (1997). The association of carbamazepine-mianserin In opiate withdrawal A double blind pilot study versus clonidine. Pharmacological Research 35 451-456. 

Mianserin has alpha-adrenoceptor activity and so might interact with clonidine (17). In healthy volunteers, pretreatment with mianserin 60 mg/day for 3 days did not modify the hypotensive effects of a single 300 mg dose of clonidine. In 11 patients with essential hypertension, the addition of mianserin 60 mg/day (in divided doses) for 2 weeks did not reduce the hypotensive effect of clonidine. The results of this study appear to have justified the authors conclusion that adding mianserin to treatment with clonidine will not result in loss of blood pressure control. 

Solutions of drugs were prepared in 145 mM aqueous NaCl, from which a dose series was prepared. dl-Octopamine, dl-synephrine, dopamine, tolazoline, clonidine, yohimbine, cyproheptadine, gramine, chlorpromazine, promethazine, propranolol, metoclopramide, and 3-isobutyl-l-methylxanthine were obtained from Sigma Chemical Co. naphazoline from Aldrich Chemical Co. chlordimeform and phentolamine from Ciba Geigy mianserin from Research Biochemicals Inc. and lofexidine, XAMI, and tramazoline were gifts from Dr. R. Hollingworth, Purdue Univ. 

Noninterfering albuterol, allopurinol, alprenolol, aspirin, atenolol, captopril, carbimazole, clonidine, coloxyl, danthron, diazepam, digoxin, doxepin, glibenclamide, hydralazine, in-domethacin, labetalol, metformin, methyldopa, metoprolol, mianserin, minoxidil, nifedipine, nitrazepam, oxazepam, oxprenolol, pindolol, prazosin, propranolol, senokot, theophylline, trifluoperazine... 

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