Clomipramine children

DeVeaugh-Geiss, J., Moroz, G., Biederman, J., Cantwell, D., Fontaine, R., Greist, J.H., Reichler, R., Katz, R., and Landau, P. (1992) Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder—a multicenter trial. / Am Acad Child Adolesc Psychiatry 31 45 9. 

Much of the time, treatment-extant literature doesn t provide much guidance when the patient has multiple comorbidities or already has failed best-practice initial interventions. The few available comparative treatment trials that include both medication and psychotherapy all focus on acute treatment or, less commonly, the heroic management of treatment-refractory patients. This leaves out the majority of patients for whom combined treatment is appropriate if not de rigueur, namely those who are partial responders to initial treatment and/or who require a combination of treatments because of comorbidity. Furthermore, for many clinically important decisions, it is unlikely that there will ever be randomized evidence. For example, how many SSRI trials should precede a clomipramine trial in the partially responsive child with OCD Flow long does one wait before adding a SSRI when treating a child with OCD who is not particularly responsive to weekly CBT ... 

Berney, T, Kolvin, I., Bhate, R.F., Carsioe, R.F, Jeans, J. Kay, B. and Scarth, L. (1981) School phobia a therapeutic trial with clomipramine and short—term outcome. Br J Psychiatry 138 110—118. Bernstein, C.A., Borchardt, C.M., Perwein, A.R., et al. (2000) Imip-ramine plus cognitive-behavioral therapy in in the treatment of school refusal./ Am Acad Child Adolesc Psychiatry 39 276—283. Bernstein, C.A., Crosby, R.D. Perwein, A.R., and Borchardt, C.M. 

DeHann, E., Hoogduin, K.A.L., Buitelaar, J.K., and Keijsers, G.P.J. (1998) Behavior therapy versus clomipramine for the treatment of OCD in children and adolescents. / Am Acad Child Adolesc Psychiatry 37 1022-1029. 

Figueroa, Y., Rosenberg, D., Birmaher, B., and Keshavan, M. (1998) Combination treatment with clomipramine and selective serotonin reuptake inhibitors for obsessive-compulsive disorder in children and adolescents. / Child Adolesc Psychopharmacol 8 61-67. 

Btodkin, E.S., McDougle, C.J., Naylor, S.T., Cohen, D.J., and Price, L.H. (1997) Clomipramine in adults with pervasive developmental disotdets a ptospective open-lahel investigation J Child Ado-lesc Psychopharmacol 7 109-21. 

McDougle, C.J., Price, L.H., Volkmar, F.R., Goodman, W.K., Ward-O Brien, D., Nielsen, J., Bregman, J., and Cohen, D.J. (1992) Clomipramine in autism preliminary evidence of efficacy. / Am Acad Child Adolesc Psychiatry 31 746-750. 

Sanchez, L.E., Campbell, M., Small, A.M., Cueva, J.E., Armenteros, J.L., and Adams, P.B. (1996) A pilot study of clomipramine in young autistic children. J Am Acad Child Adolesc Psychiatry 35 537-544. 

In 1995, Bramble published a study on the prescription frequency of antidepressants by British child psychiatrists (Bramble, 1995). A brief postal questionnaire was circulated to 350 members of the British Royal College of Psychiatrists, Child and Adolescent Psychiatry Specialist Sections. There was a 71% response rate, and 85% of the 238 respondents had employed antidepressants, the most popular of these being amitriptyline and imipramine. Nearly one-third of the psychiatrists at that time used neuroagents occasionally, and the SSRIs were used only very rarely. The antidepressant medication was used for a wide range of child and adolescent disorders beyond those of depression and nocturnal enuresis. Approximately 20% of the prescriptions were given for ADHD (hyperkinetic disorder), conduct disorder, and a few cases of autistic disorder. Clomipramine was apparently given for OCD. On the basis of these 1994 data. Bramble concluded that British child psychiatrists tend to use antidepressant medication far less often than American psychiatrists. 

McDougle CJ, Price LH, Volkmar FR, et al Clomipramine in autism preliminary evidence of efficacy. J Am Acad Child Adolesc Psychiatry 31 746-750, 1992... 

Bloem BR, Lammers GJ, Roofthooft DW, De Beaufort AJ, Brouwer OF. Clomipramine withdrawal in newborns. Arch Dis Child Fetal Neonatal Ed 1999 81(1) F77. 

Leonard HL, Meyer HC, Swedo SE, et al. Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents. J Am Acad Child Adolesc Psychiatry 1995 34 1460-1468. 

Braconnier, A., R. Le Coent, and D. Cohen. Paroxetine versus clomipramine in adolescents with severe major depression a double-blind, randomized, multicenter trial. /. Am. Acad. Child Adolesc. Psychiatry 42 (2003) 22-9. 

Fisman S, Diaz P. Erythromycin and clomipramine Noncompetitive inhibition of demethyla-tion. Reply. J Child Adolesc Psychopharmacol (1996) 6, 213. 

---