Cliona celata

Lenis, L., Nunez, L., Jimenez, C., and Riguera, R., Isonitenin and acetylhomoagmatine, new metabolites from the sponges Spongia officinalis and Cliona celata collected at the Galician coast (N.W. Spain), Nat. Prod. Lett., 8, 15, 1996. 

Two brominated linear peptides that are found in the sponge Cliona celata, celenamide A (21 R = CH2CHMe2) and celenamide B (21 R = CHMe2), bear close structural relationships to the cyclic peptides integerrin and lasiodine A that occur in plants.16 A I3C n.m.r. analysis of cyclic peptide alkaloids has been reported and the chemical shifts of most of the carbon atoms in discarines A and B, lasiodines A and B, pandamine, pandaminine, and hymenocardine have been assigned.17... 

Hatch, W., 1975. The Implication of Carbonic Anhydrase in the Physiological Mechanism of Penetration of Carbonate Substrate by the Marine Burrowing Sponge Cliona celata. Unpubl. Ph.D. Diss., Boston University, 158 pp. 

Stonard, R.J., and RJ. Andersen Linear Peptide Alkaloids from the Sponge Cliona celata (Grant). Celenamides C and D. Can. J. Chem., 58, 2121 (1980). 

Cliona celata has furnished a series of linear peptide alkaloids, the celenamides A to D (278-281), in addition to the previously known clionamide (282) (168, 169). These compounds were isolated in the form of their polyacetates after acetylation of the methanolic extract of the homogenized sponge. The celenamides contain a unique amino acid a,P-didehydro-3,4,5-trihydroxyphenylalanine, as a subunit. The configuration of the double bond in the dehydroamino acid residue has been determined by synthesis of the hexa-acetate of 278 (170). 

Isolated from the South African sponge Cliona celata, clionamines A-D are novd aminosteroids that intervene in autophagocytosis, a complex catabolic process of cell components through the lysosome (Keyzers et al, 2008). 

Stonard, R.J. and Andersen, R.J. (1980a) Celenamides A and B, linear peptide alkaloids from the sponge Cliona celata. J. Org. Chem., 45, 3687-3691. 

Litchfield, C., Tyszkiewicz, J., Marcantonio, E.E., and Noto, G. (1979) 15,18,21,24-Triacontatetraenoic and 15,18,21,24,27-triacontapenta-enoic acids new C30 fatty acids from the marine sponge Cliona celata. Lipids, 14, 619-622. 

Keyzers, R.A., Daoust, J., Davies-Coleman, M.T., Van Soest, R Balgi, A., Donohue, E Roberge, M and Andersen, R.J. (2008) Autophagy-modulating aminosteroids isolated from the sponge Cliona celata. Org. Lett.. 10,2959-2962. 

The recognition that sponges contain a variety of sterols which vary from one species to another was first reported in a classical paper by Doree 74). This author isolated a sterol from the sponge Cliona celata which he named clionasterol and showed to be different from both cholesterol and spongosterol. The latter, earlier isolated from a mediterranean sponge 114), was the first animal sterol to be recognized as different from cholesterol. 

In 1972 ten years after the appearance of the last of Bergmann s reviews (77), Erdman and Thomson reported an investigation on the sterols from two British species. Cliona celata and Hymeniacidon perleve... 

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