Peptidomics clinical

At first glance, blood is the ideal sample from which to obtain a representative clinical sample suitable for peptide research. However, its complexity and the high abundance of certain proteins, such as albumin, fibrinogen, and immunoglobulins, render blood probably the most difficult of all proteomic samples 

In addition to the efforts in the biotech and pharmaceutical industries, a comprehensive, multinational approach to unraveling this biological source has already started with the emergence of the Human Plasma Proteome Project. 

Peptides from the insulin precursor are good examples for peptide biomarkers present in blood. Insulin itself is used as a therapeutic compound but, at the same time, it is also used as a biomarker to diagnose diabetes (Table 6.2). In addition, byproducts released during hormone processing are used as diagnostics. 

Brain natriuretic peptide (BNP) 3.5 Congestive heart failure 

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The rapid progress in proteomics and peptidomics during the last decade offers us new possibilities to study clinical aspects of disorders and diseases related to the brain [1], These strategies also offer new tools to follow chemical modifications and altered metabolic disturbances that may be indicative of pathophysiological adaptations related to environmental and psychosocial prolonged stress. These techniques can contribute to developments in the diagnostic and therapeutic fields of psychiatric... 

Taking advantage of the methodologies referred in the preceding text, the systematic study of all salivary secretory peptidome components, PTMs, and protein-peptide complexes has been the initial key step of saliva basic knowledge for further application to clinical applications (52-56). Besides their potential use as biomarkers, salivary peptides have been studied so far mainly in relation to their function in the oral cavity, for example, in the modulation of enamel mineralization (57,58), diurnal variations (45), age-dependent modifications (11,27,59), or diet influence (60). 

Many recent studies have been focused on the impact of diseases on salivary peptidomics envisioning their clinical diagnosis (6,71-73), including systemic... 

Davidsson, P., Brinkmalm, A., Karlsson, G., et al., 2003. Clinical mass spectrometry in neuroscience. Proteomics and peptidomics. Cell. Mol. Biol. 49,681-688. 

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