Pseudo-membranous colitis

Clindamycin shows in vitro activity against Pro-pionibacterium acnes and topically applied clindamycin is effective for the treatment of acne. Approximately 10% of an applied dose is absorbed. In spite of this absorption pseudo-membranous colitis with bloody diarrhea is seldom seen. 

Stool culture for pathogens, notably salmonel-lae and shigellae, and examination for the exotoxin of Clostridium difficile in pseudo-membranous colitis, are important considerations in acute disease. C. difficile requires oral vancomycin or metronidazole treatment, and giardiasis generally responds to metronidazole. 

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