Clindamycin CLEOCIN

Clindamycin (Cleocin) 300 mg orally twice daily for 7 days Oral administration is second-line agent in pregnancy ... 

Clindamycin (Cleocin) 900 mg intravenously every 8 hours until delivery ... 

Aztreonam (Azactam) Clindamycin (Cleocin, Cleocin-T, others) Fosfomycin (Monurol) Linezolid (Zyvox) Metronidazole (Flagyl, MetroGel)... 

The lincosamide family of antibiotics includes lin-comycin (Lincocin) and clindamycin (Cleocin), both of which inhibit protein synthesis. They bind to the SOS ri-bosomal subunit at a binding site close to or overlapping the binding sites for chloramphenicol and erythromycin. They block peptide bond formation by interference at either the A or P site on the ribosome. Lincomycin is no longer available for human use in the United States. 

Gentamicin (Garamycin) Erythromycin estolate (llosone) Doxycycline (Monodox, Vibramycin, others) Clindamycin (Cleocin)... 

Lincomycin has generally been replaced by Clindamycin (Cleocin) because there are significant occurrences of pseudomembranous colitis in patients who use lincomycins. Clindamycin is a semisynthetic derivative of lincomycin that is safer and more effective than lincomycin. 

Resistant strains of P. acnes are emerging that may respond to jndicions nse of retinoids in combination with antibiotics. Commonly nsed topical antimicrobials in acne inclnde erythromycin, clindamycin (Cleocin-t), and benzoyl peroxide and antibiotic-benzoyl peroxide combinations (Benzamycin, Benzaclin, others). Other antimiaobials nsed in treating acne inclnde sulfacetamide (Klaron), sulfacetamide/sulfur combinations (Snlfacet-R), metronidawie (Metrocream, Metro-Gel, noritate), and azelaic acid (Azelex). Systemic therapy is prescribed for patients with more extensive disease and acne that is resistant to topical therapy. Effective agents inclnde tetracycline (snmycin, others), minocycline (MINO-CIN, others), erythromycin (ERYC, others), clindamycin (CLEOCIN), and trimethoprim-sulfamethoxazole (bactrim, others). Antibiotics nsnally are administered twice daily, and doses are tapered after control is achieved. 

This chaj)ter discusses three groups of broad-spectrum antibiotics the tetracyclines, tlie macrolid, and the lincosamides. Example of the tetracycline include doxycycline (Vibramycin), minocycline (Minocin), and tetracycline (Sumycin). Examples of the macrohde include azithromycin (Zitliromax), clarithromycin (Biaxin), and erytliromycin (E-Mycin). The lincosamides include clindamycin (Cleocin) and lin-comycin (Lincocin). The Summary Drug Table Tetracyclines, Macrolide, and Lincosamide describe the lyi es of broad-spectrum antibiotics discussed in tliis chapter. 

Clindamycin (Cleocin) Lincomycin (Lincocin) Binds to 50s ribosomal subunit. Prevents protein synthesis. Exact mechanism unknown. Covers Gram-positives and most anaerobes. Clindamycin is more potent than lincomycin. Clindamycin is drug of choice for anaerobic Gl infections. Also used for B. fragilis infections. Lincomycin is infrequently used for Staphylococcal infections. 

Lincomycin (Lincocin) has been used in the past to treat serious streptococci, pneumococci, and staphylococci infections but has generally been replaced by safer and more effective antibiotics. Clindamycin (Cleocin) is a semisynthetic derivative of lincomycin and has a similar mechanism but is more effective. It is indicated for the treatment of bone and joint infections, pelvic (female) and intraabdominal infections, bacterial septicemia, pneumonia, and skin and soft tissue infections. In a normal dose, lincosamides prevent the growth of bacteria (bacteriostatic). In larger doses, it kills bacteria (bacteriocidal). 

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