Clearance linear

Clearance Linear, fast, constant N-NAB Linear, fast, constant NAB Linear, slow, constant N-NAB Linear, slow, constant NAB Nonlinear, fast, constant N-NAB Nonlinear, fast, constant NAB Nonlinear, fast, variable N-NAB Nonlinear, fast, variable NAB Nonlinear, slow, constant N-NAB Nonlinear, slow, constant NAB Nonlinear, slow, variable N-NAB Nonlinear, slow, variable NAB... 

Clearance linearity with respect to dose (power -0.457 + 0.0243... 

Methilites. Liq expls developed in the USA during WWII for use in linear charges for mine field clearance. Typical, of these were ... 

As previously noted, the bioavailability of a compound is a complex function that includes contributions from absorption and clearance. Since the molecule must undergo these biological processes in all species, there is a temptation to assume a relationship between the bioavailability between species, and hence that human bioavailability can be predicted by such relationships. Although a linear correlation has been demonstrated for the rate/extent of absorption (% oral dose absorbed) between species for various drugs [6-8], there is clearly a lack of correlation for bioavailability between species [2, 8]. Figure 19.1 shows the excellent correlation in... 

It is important to remember that absolute oral bioavailability is a function of both absorption and first-pass metabolism. Therefore, a linear approach to predicting absolute oral bioavailability based on a single parameter, such as rate or extent of absorption (fraction of dose absorbed or estimated dose absorbed) or the rate of metabolism (microsomal or hepatic intrinsic clearance), may result in an inaccu-... 

Renal elimination of unchanged drug accounts for 66% of drug clearance, and the dose should be adjusted for impaired renal function. The role of therapeutic drag monitoring is unknown. It has linear pharmacokinetics and is metabolized in blood by nonhepatic enzymatic hydrolysis. 

Calculations of displacements and rotations at specific locations may be required where clearance problems are involved. In cases where small-size branch pipes attached to stiffer run pipes are to be calculated separately, the linear and angular movements of the junction point must be calculated or estimated for proper analysis of the branch. 

Neural networks are a relatively new tool in data modelling in the field of pharmacokinetics [54—56]. Using this approach, non-linear relationships to predicted properties are better taken into account than by multiple linear regression [45]. Human hepatic drug clearance was best predicted from human hepatocyte data, followed by rat hepatocyte data, while in the studied data set animal in vivo data did not significantly contribute to the predictions [56]. 

E = 137keV). The accompanying emission of 7-radiation can be used for scintigraphic imaging but also makes patient isolation necessary. The different half-lifes and /3 -energies allow individual therapeutic demands such as the pharmacokinetics of the tracer molecule, the linear energy transfer of the nuclides or the biodistribution and clearance of the radiolabeled drug to be met. The principles of the application of radioactive materials for therapy are summarized in an excellent review. ... 

Saturable clearance mechanisms producing non-linear kinetics... 

---