Linear energy transfer

Modulation of the Killing of Mammalian Cells by Thiols. Important aspects of the effects of exogenous thiols on clonogenic cell survival following exposure to low linear energy transfer (LET) radiations include the following. 

Linear Energy Transfer (LET)—A measure of the energy that a charged particle transfers to a material per unit path length. 

Quality Factor (Q)—The linear-energy-transfer-dependent factor by which absorbed doses are multiplied to obtain (for radiation protection purposes) a quantity that expresses - on a common scale for all ionizing radiation - the approximate biological effectiveness of the absorbed dose. 

Linear energy transfer (LET) kiloelectron volts per micrometer (keV pm"1) 1.602xl0"10 Jm"1 kiloelectron volts per micrometer (keV im ) 1.602x1 O 10 Jm 1... 

The range in tissues and linear energy transfer (LET) depend on the type of radiation emitted and its energy. The potent lethality of Auger and low-energy conversion electrons is demonstrated by intranuclear localization of the radioisotope due to their short ranges (about one cell nucleus in diameter). Alpha particles have ranges of several cell diameters (40-90 pm) and are effective in... 

Stopping power or linear energy transfer (LET) is the energy lost per unit path length. Equation 6-2 expresses this relationship. 

S = stopping power LET = linear energy transfer AE = energy lost AX = path length of travel... 

Linear energy transfer (LET) A function of the capacity of the radiation to produce ionization. LET is the rate at which charged particles transfer their energies to the atoms in a medium and a function of the energy and velocity of the charged particle. See Radiation dose. 

Linear Energy Transfer. The concept of linear energy transfer (LET) has been a useful one in rationalising the variation in radiolytic yields found for different types of radiation. It is still widely... 

Linear Energy Transfer International Commission on Radiological Units and Measurements Washington, D.C., 1970 Report No. 16. 

Because of the high linear energy transfer (LET) of the particles produced by the 10B(n,a)7Li reaction, the production of secondary ions is not enhanced in the presence of oxygen with low-LET radiation such as external photon irradiation, tissues... 

E = 137keV). The accompanying emission of 7-radiation can be used for scintigraphic imaging but also makes patient isolation necessary. The different half-lifes and /3 -energies allow individual therapeutic demands such as the pharmacokinetics of the tracer molecule, the linear energy transfer of the nuclides or the biodistribution and clearance of the radiolabeled drug to be met. The principles of the application of radioactive materials for therapy are summarized in an excellent review. ... 

Linear energy transfer has often been shown to be a poor parameter for characterizing product yields. Therefore in order to compare the results for the different ions the MZ jE parameter has been used. This parameter has been successfully used in the past and seems to work well for the data presented here. Note that an increase in MZ jE corresponds to an increase in LET so product trends as a function of MZ jE presented here are comparable to similar discussions in the literature using LET. Unfortunately, there is no good formalism to fit product yields as a function of MZ jE. The solid lines in Figs. 9-14... 

Radiation quality is defined by the nature, charge, and energy spectrum of the particles and can be characterized by the linear energy transfer (LET) or, alternatively, by the micro-dosimetric spectra at the point of interest under the actual irradiation conditions. 

The radiobiological rationale for introducing high linear energy transfer (LET) radiation in cancer therapy, as proposed in the 1960s, is still valid and has not been contradicted by more recent radiobiological findings [3]. 

---