Clear-cell meningioma

Clear Cell Meningioma (WHO Grade II as an Intracranial Tumor)... 

Alameda F, Lloreta J, Ferrer MD, et al. Clear cell meningioma of the lumbo-sacral spine with chordoid features. Ultrastruct Pathol. 1999 23 51-58. 

Figure 20.1 shows a cerebral tumor from the lumbosacral region of a middle-aged woman. The H E-stained slide reveals a neoplasm with mainly epithelioid cells and a few clear cells, and abundant round to oval nuclei with fine chromatin (Table 20.6 see Fig. 20.lA). Its IHC is focally positive to epithelial membrane antigen (EMA) (see Fig. 20.IB). Boxes 20.1 and 20.2 show carcinoma, chordoma, craniopharyngioma, pituitary adenoma, and meningioma to be EMA positive. This tumor is negative for cytokeratin (CK) CAM5.2 (see Fig. 20.1C), so it does not fit the immunohistochemical...

Fits into a well-differentiated subtype (text) (WHO grade II is assigned to clear cell and chordold meningiomas) (WHO grade III is assigned to rhabdoid and papillary meningiomas)... 

The potential applications of therapy to areas outside the liver are numerous. Any site in the body that is angiographically accessible may potentially be considered for therapy. This would include meningiomas, glioblastoma multiforme, renal cell carcinomas, head/neck and lung tumors. Given that skin necrosis following has been described, the cutaneous contribution of the extra-hepatic vasculature being examined would have to be taken into consideration [14]. Clearly, very carefully controlled in-vitro, animal and phase I safety studies with small patient cohorts are required before widespread clinical applications in these areas are explored. 

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