Cleaning Installations, Sterilization by Steam and Vaporized Hydrogen Peroxide VHP

Cleaning Installations, Sterilization by Steam and Vaporized Hydrogen Peroxide (VHP ) 

Cleaning and sterilization of freeze-dryers are two process steps with the highest priority in aseptic production systems. The rule CIP is followed by SIP is applied here. 

To attain a high degree of cleaning, the four T Principles [Wolpers, Frank Clean-in-Place Systems for the Pharmaceutical Industry VDMA Seminar, Interphex 2001, Philadelphia] must be taken into account  

Temperature — Thermal effect an increase in temperature of 1 °C increases the cleaning efficiency by 5% (over 30 °C). 

Caution with proteins, too hot a cleaning medium will cause the dirt particles to burn on to the surfaces of the shelves and walls. Pre-cleaning at 40 °C is, therefore, advisable. 

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