1 Classification reactions Anhydrides

Phosphine(s), chirality of, 314 Phosphite, DNA synthesis and, 1115 oxidation of, 1116 Phospholipid, 1066-1067 classification of, 1066 Phosphopantetheine, coenzyme A from. 817 structure of, 1127 Phosphoramidite, DNA synthesis and, 1115 Phosphoranc, 720 Phosphoric acid, pKa of, 51 Phosphoric acid anhydride, 1127 Phosphorus, hybridization of, 20 Phosphorus oxychloride, alcohol dehydration with. 620-622 Phosphorus tribromide, reaction with alcohols. 344. 618 Photochemical reaction, 1181 Photolithography, 505-506 resists for, 505-506 Photon, 419 energy- of. 420 Photosynthesis, 973-974 Phthalic acid, structure of, 753 Phthalimide, Gabriel amine synthesis and, 929... 

OSHA PEL CL 5 mg(Mn)/m3 ACGIH TLV TWA 5 mg(NIn)/m3 DOT CLASSIFICATION 5.1 Label Oxidizer SAFETY PROFILE Probably a severe irritant to the skin, eyes, and mucous membranes. A powerful oxidizer and fire hazard. Explosive reaction with acetic acid, acetic anhydride. Reacts vigorously with combustibles. When heated to decomposition it emits toxic fumes of Na20. See also MANGANESE COMPOUNDS, PERMANGANATES, and POTASSIUM PERMANGANATE. 

DOT CLASSIFICATION 8 Label Corrosive DOT Class 8 Label Corrosive, Poison SAFETY PROFILE Confirmed human carcinogen. A poison. Moderately toxic by inhalation. A corrosive irritant to skin, eyes, and mucous membranes. A very dangerous fire hazard by chemical reaction with reducing agents and carbohydrates. A severe explosion hazard by chemical reaction with acetic acid, acetic anhydride, acetonitrile, acrolein, acrylic acid, acrylonitrile, aUyl... 

Although oxoacids and hydroxides are Arrhenius acids and bases (they release or OYi (aq) into aqueous solution), acid and base anhydrides do not fall into this classification because they contain neither nor OH. Acid anhydrides are acids in the Lewis sense, (they accept electron pairs), and base anhydrides are bases in the Lewis sense, (their ions donate electron pairs). The reaction between an acid anhydride and a base anhydride is then a Lewis acid-base reaction. An example of such a reaction is... 

Aminoquinazolines are of considerable medicinal interest and may be synthesized by a one-pot reaction from isatoic anhydride (isatoic anhydride have been reviewed [3(X)8]. 

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