Ciprofloxazine

Another way to control the release of biocides is to entrap them into a matrix that is slowly hydrolyzed, e.g., into polylactic acid or other polyesters [104, 105] or degradable polyelectrolyte multilayers [106], By choosing a matrix that is degradable by a specific enzyme, the location of release in the body can be controlled. An example of this approach, which is very common for drug release but rarely used for biocides, is fluoroquinolone-modified biodegradable polyurethane that releases the antibiotic ciprofloxazin upon degradation catalyzed by the enzyme cholesterol esterase [107],... 

The synthesis of ciprofloxazin was one among several syntheses being performed in contract research by a microreactor developer for pharmaceutical industry and feasibility was demonstrated [32], In this multistep synthesis, alkylamino-defluorinations were the essential part of the chemistry. Ciprofloxazin, the final product, is an antibiotic compound with a high sales volume. 

Scheme 4.12 Examples of fluorine

Many quinoline derivatives are important biologically active agents. 8-Hydroxyquinoline and some of its halogenated derivatives are used as antiseptics. Chloroquine 111 is one of the older but still important antimalarials. A -Alkyl-4-quinolone-3-carboxylic acid and systems derived therefrom are constituents of antibacterials (gyrase inhibitors [112]) such as nalidixic acid 112, ciprofloxazin 113 and moxifloxazin 114. The quinoline-8-carboxylic acid derivative 115 (quinmerac) is employed as a herbicide for Galium aparine and other broad-leaved weeds. Methoxatin 116, known as coenzyme PQQ is a heterotricyclic mammalian cofactor for lysyl oxidase and dopamine P-hydroxylase [113]. 

Ciprofloxazin 406 Click chemistry 262 Cocaine 433 Codonopsin 576 Coelenterazine 485 Collidine 345 Coniine 432... 

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