Ciprofloxazin Multistep Synthesis

The synthesis of Ciprofloxazin was one among several syntheses being performed in contract research by a microreactor developer for pharmaceutical industry and feasibility was demonstrated [40]. In this multistep synthesis, alkylaminodefluori-nations were essential part of the chemistry. Ciprofloxazin, the final product, is an antibiotic compound with a high sales volume. 

This reaction scheme involves two substitutions of fluorine moieties at the aromatic ring by amines, yielding the final product for pharmaceutical applications [40,41]. All in all, five synthesis steps are actually required and performed subsequently in a microreactor system to get the target molecule. 

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