Ciprofloxacin plague

Prophylaxis For asymptomatic patients exposed to plague aerosol, or to a patient with suspected pneumonic plague, provide doxycycline at 100 mg orally twice daily for seven days, or for the duration of risk of exposure plus one week. Alternative antibiotics include ciprofloxacin, tetracycline, or chloramphenicol. No vaccine is currently available for plague propylaxis. The previously available licensed, killed vaccine was effective against bubonic plague, but not against aerosol exposure. 

The historical antibiotic of choice for the treatment of plague has been streptomycin. Gentamicin is another preferred antibiotic. Alternative regimens include doxycycline, ciprofloxacin, and chloramphenicol. Patients with pneumonic plague may also require advanced medical supportive therapy in addition to antibiotics. 

As for the treatment of plague, streptomycin and gentamicin are the drugs of choice. Doxycycline and chloramphenicol have also been used, but more treatment failures have been reported with these regimens. Ciprofloxacin is another alternative therapy. For the first-line regimens as well as ciprofloxacin, a 10-day course of intravenous antibiotics is recommended. For second-line therapies, 14 days are recommended. 

During a pneumonic plague epidemic, all persons developing a fever of 38.5°C or above or a new cough should begin parenteral antibiotics (23). Infants with tachypnea should also receive treatment (23). In a mass outbreak, in which parenteral therapy may not be available, the Working Group recommends oral therapy for adults with doxycycline (or tetracycline or ciprofloxacin) children should receive doxycycline (see Table 2.11). 

Y. pestis in experimentally infected fleas and monkey blood and oropharyngeal swabs. The signal is detected and interpreted by the ABl 7700 Sequence Detector (Applied Biosystems, Foster City, Calif.), a combination of thermal cycler, laser, and detection per software system [60]. (c) PCR-based assay, with FRET registration, was used to detect ciprofloxacin-resistant (CpO mutants of plague. It was possible to distinguish the wild type from antibiotic-resistant type, and detect approximately 10 pg of DNA (or 4 CFU, colony forming units) of wild-type F. pestis KIM 5 or Cp mutants in crude lysates [61]. 

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