Ciprofloxacin INDEX

Theophylline is a narrow therapeutic index drug with significant difference in bioavailability following oral administration. The half-life of the drug is increased by heart failure, cirrhosis and viral infections, in elderly patients, and by certain drugs, such as cimetidine, ciprofloxacin, oral contraceptives and fluvoxamine. The half-life is decreased in smokers, chronic alcoholism, and by certain drugs, such as phenytoin, rifampicin and carbamazepine. 

To prevent secondary cases of meningococcal disease prophylaxis with rifampicin 600 mg orally twice daily for two days is recommended for close contacts with the index case. A single dose of 500 mg ciprofloxacin orally is also effective in eliminating nasopharyngeal carriage of N. meningitidis. 

Based on current information, inhibitors of CYP 1A2 have the greatest potential for causing interactions with olanzapine. Examples include cimetidine, fluvoxamine, and fluoroquinolone antibiotics (e.g., ciprofloxacin) to varying degrees. To date, however, no serious inhibition interactions have been reported with olanzapine, which may be a result of olanzapine s wide therapeutic index. Carbamazepine has been reported to increase olanzapine elimination by as much as 50%. Cigarette smoking is a potent inducer of CYP 1A2, and one would expect lower mean olanzapine serum concentrations in smokers compared to nonsmokers. 

Gonorrhea Contacts of index case Cefixime or ceftriaxone Ciprofloxacin and ofloxacin are alternatives... 

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