Probenecid Cinoxacin

Cinoxacin is contraindicated in patients with known hypersensitivity to the individual drug and in patients with anuria. Cinoxacin is a Pregnancy Category B drug and should be used with caution during pregnancy and lactation. Cinoxacin is used with caution in patients with hepatic impairment. When cinoxacin is administered with probenecid, there is a risk for lowered urine concentration of cinoxacin. 

Israel KS et al. (1975). Cinoxacin pharmacokinetics and the effect of probenecid. J Clin Pharmacol 18 491-499. 

Probenecid increases the serum ieveis and/or decreases the urinary excretion of cinoxacin, ciprofloxacin, clinafloxacin, enoxacin, fleroxacin, levofloxacin, nalidixic acid and norfloxacin. The ciinicai importance of these changes is uncertain, but is seems iikeiy they wiii oniy be important in the presence of other drugs that aiso affect renai excretion. Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact with probenecid. 

A study in 6 healthy subjects found that probenecid 500 mg three times daily roughly doubled the serum levels of a 3-hour intravenous infusion of cinoxacin. The renal clearance of cinoxacin was also reduced from 68 to 46% during and for the 4 hours after the infusion. ... 

Rodriguez N, Madsen PO, Welling PG. Influence of probenecid on serum levels and urinary excretion of cinoxacin Antimicrcb Agents Chemo er (1979) 15, 465-69. 

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See also in sourсe #XX -- [ ]

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