Chronic proliferative dermatitis

Key words Skin, alopecia areata, atopic dermatitis, chronic proliferative dermatitis, full thickness skin grafts, hair, xenograft. 

Fig. 12.3. Epidermal measurements, mitotic figures, and apoptotic keratinocytes in a chronic proliferative dermatitis mutant (Sharplncpdm/Sharplncpdm) mouse. Routine hematoxylin- and eosin-stained paraffin histologic sections can be used to determine proliferation rates based on mitotic index (number of mitotic figures, circled in the figure, in the stratum basale per 1000 cells) or the presence and numbers of apoptotic epidermal keratinocytes (dotted arrows) when present. Epidermal thickness can be measured at high dry magnification (40x) to include the malpigian, living cell, layer (M), the stratum corneum thickness (SC), or the full thickness of the epidermis (M+SC).

Fig. 12.4. Bromodeoxyuridine (BRDU) labeling of cells in S phase. Routine paraffin sections from mice injected 1 h prior to euthanasia with BRDU have brown nuclei when labeled by immunohistochemistry using diaminobenzidine as a chromogen. These cells were synthesizing DNA at the time of necropsy and therefore incorporated the label. Counting the number of positive nuclei in basal cells per 1000 basal cells yields the proliferation rate. The boxed area in A is enlarged in B to illustrate the large number of positive (dark) nuclei in the skin of an adult chronic proliferative dermatitis mutant mouse (Sharpincpdm/Sharpincpdm).

Chronic Proliferative Dermatitis The chronic proliferative dermatitis mutant mouse is one of a number of mouse models proposed for psoriasis. This spontaneous mutant was recently shown to be caused by a mutation in the Sharpin gene (86). This mouse model was used to screen recombinant human cytokines in which recombinant interleukin 12 (IL-12) but not interleukin 11 (IL-11) effectively corrected the skin disease (28). 

D., Sundberg, B. A., Carroll, J. and Sundberg, J. P. (2001) Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and... 

Psoriasis is a chronic proliferative inflammatory skin condition. The severity of the condition ranges from mild focal involvement to generalised exfoliative dermatitis. The clinical course is also unpredictable. 

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