Chromosomes malignancy

Transmission is autosomal dominant, and the relevant gene has been mapped to the same locus on chromosome 19q as that associated with susceptibility to malignant hyperthermia (pages 318-319). It is not established that the conditions are allelic. Almost all patients with CCD whose muscle has been tested in vitro for... 

B and T cells can undergo neoplastic transformation that is governed by specific mutations in their chromosomes that result in populations of malignant lymphoma cells. 

Chromosomal translocations have become a hallmark of many lymphomas and are helpful in the diagnosis and classification of lymphoid malignancies. NHL often involves extranodal sites and does not spread through contiguous lymph nodes. 

Veldman, T., Vignon, C., Schrock, E., Rowley, J. D., and Reid, T. (1997) Hidden chromosome abnormalities in hematological malignancies detected by multi-colonr spectral karyotyping. Nat. Genet. 15, 406 10. 

Ataxia telangiectasia is an autosomal recessive disease characterized by neurologic, endocrine, and hepatic abnormalities, as well as a predisposition to malignancy (119). The defect has been traced to a gene on chromosome 11, the ATM gene that codes for a phosphatidylinositol 3-kinase-like protein which is related to the catalytic subunit of DNA-dependent protein kinase. This protein has a role in signal transduction, DNA repair, and control of the cell cycle (120). Affected patients have a defect in cell-mediated immunity. A decrease in semm IgA is seen in a majority of affected patients. IgG2 or total IgG and IgE levels may be decreased, with an increase in IgM. Patients are susceptible to chronic respiratory... 

The vinca alkaloids comprise vincristine and vinblastine. These complex, heterocyclic alkaloids are derived from the periwinkle plant. Vindesine and vi-norelbine are semisynthetic analogues. These drugs are M-phase specitic. Binding specifically to tubulin they inhibit the polymerization of microtubules. The consequent ineffective chromosome segregation initiates apoptosis for both normal and malignant cells. 

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