Marker chromosomes

Bacillus subtilis transformants were identified by their resistance to naphthalene, parachlorobiphenyl, or dibenzofuran. Controls subtilis protoplasts regenerated without the addition of B. megaterium plasmid DNA) exhibited no increased reistance to these three compounds. That each transformant was B. subtilis and not a contaminant was verified by testing for the B. subtilis chromosomal markers. Only streptomycin resistant strains that showed arginine and leucine dependent growth were used in subsequent experiments. 

Berretini WH, Goldin LR, Gelernter S, et al. X-chromosome markers and manic depressive illness rejection of linkage to xq28 in nine bipolar pedigrees. Arch Gen Psychiatry 1990 47 366-373. 

Baron M, Risch N, Hamburger R, et al. Genetic linkage between X-chromosome markers and bipolar affective disorders. Nature 1987 326 289-292. 

Henle W, Diehl V, Kohn G et al. Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells. Science 1967 157 1064-1065. 

Y-chromosome markers are listed m their major haplotype groups. 

Y-chromosome markers in conjunction with a large database of typed individuals. 

A13. Alter, A. A., Lee, S. L., Pourfar, M., and Dobkin, G., Studies of leukocyte alkaline phosphatase in mongolism. A possible chromosome marker. Blood 22, 165-177... 

Currently one research group argues in favor of a crucial role of genetic factors. They identified a specific chromosome marker (3q25) in Balkan nephropathy patients [24-26]. Another research team saw some aberrations of the X chromosome, but they resembled changes occurring after exposure to ocharatoxin A [27]. 

A EXPERIMENTAL FIGURE 10-5 Simple-sequence DNAs are useful chromosomal markers. Human metaphase chromosomes stained with a fluorescent dye were hybridized in situ with a particuiar simpie-sequence DNA iabeied with a fluorescent biotin derivative. When viewed under the appropriate wavelength of light, the DNA appears red and the hybridized simple-sequence DNA appears as a yellow band on chromosome 16, thus locating this particular simple sequence to one site in the genome. [See R. K. Moyzis et at, 1987, Chromosoma 95 378 courtesy of R. K. Moyzis.]... 

Table 2. Chromosomes, markers and ADA-CRM in the hybrids and a Chinese hamster line.

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