Moving bed chromatography simulated

Nieoud R. M., Seidel-Morgenstem A. (1993) Adsorption Isotherms Experimental Determination and Applieation to Preparative Chromatography Simulated Moving Bed Basics and Applications, R. M Nieoud (ed.), Institut National Polyteehnique de Lorraine, Naney, Pranee, p. 4-34. 

Keywords Preparative chromatography, Simulated moving bed chromatography, Continuous separation technique, Triangle theory, Bioseparation... 

When compared to the batchwise preparative chromatography, Simulated moving bed (SMB) units exhibit a number of advantages. These advantages are primarily because of the continuous nature of the operation and the efficient use of the stationary and mobile phases, which allows a decrease in desorbent requirement and an improvement of the productivity per unit time and per unit mass of stationary phase. In addition, high performances can be achieved even at rather low values of selectivity and with a relatively small number of theoretical plates. Due to these positive features, SMB is particularly attractive in the case of enantiomer separations, since it is difTicult to separate enantiomers by conventional techniques. More recent applications related to chiral technology were reported [1-3]. 

The sorption applications include regeneration of porous beds, preparative scale supercritical chromatography, simulated moving beds, thermal swing schemes, and adsorp-tion/desorptions cycles. Although initial applications of supercritical fluids in this domain were on regeneration of porous beds, more recent emphasis on fractionation best reflects... 

Chromatography may also be advantageous when it is required to separate several pure products from a single feed stream. A simulated moving-bed system can yield only two weU-separated fractions from a single feed stream. 

On that basis, crystallization is often used in combination with other enantiose-lective techniques, such as enantioselective synthesis, enzymatic kinetic resolution or simulated moving bed (SMB) chromatography [10, 11]. In general, when referring to crystallization techniques, the aim is to obtain an enantiomeric enrichment in the crystallized solid. However, the possibility of producing an enrichment in the mother liquors [12, 13], even if this is not a general phenomenon [14], must be taken into account. 

Erancotte E., Richert P. (1997) Applications of Simulated Moving-Bed Chromatography to the Separation of the Enantiomers of Chiral Drugs, J. Chrotnatogr. A 769 101-107. 

Guest D. W. (1997) Evaluation of Simulated Moving Bed Chromatography for Pharmaceutical Process Development, J. Chromatogr. A 760 159-162. 

Zhong G., Guioehon G. (1996) Analytieal Solution for the Linear Ideal Model of Simulated Moving Bed Chromatography, Chem. Eng. Sci. 51 4307-4319. 

Mazzotti M., Storti G., Morbidelli M. (1997) Optimal Operation of Simulated Moving Bed Units for Nonlinear Chromatographie Separations, J. Chromatogr. A 169 3-24. 

Pais L. S., Loureiro J. M., Rodrigues A. E. (1997b) Modeling, Simulation and Operation of a Simulated Moving Bed for Continuous Chromatographie Separation of l,l -bi-2-naphthol Enantiomers, J. Chromatogr. A 169 25-35. 

Nieoud R. M., Euehs G., Adam P, Bailly M., Kusters E., Antia E, Reuille R., Sehmid E. (1993) Preparative Seale Enantioseparation of a Chiral Epoxide Comparison of Liquid Chromatography and Simulated Moving Bed Adsorption Teehnology, Chirality 5 267-271. 

The design of simulated moving bed chromatography and its application to the separation of cycloheptanone and cyclopentanone as test substances to validate the system for subsequent chiral chromatography has been described.27 Briefly, eight silica-packed columns were hooked up in series to form a cyclic flow path. On the first pair, preliminary separation of the components was performed, with the less-retained raffinate being directed to waste. Following the second pair of columns, eluent was added. After the... 

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