Preparative chromatography simulated moving bed

Nieoud R. M., Seidel-Morgenstem A. (1993) Adsorption Isotherms Experimental Determination and Applieation to Preparative Chromatography Simulated Moving Bed Basics and Applications, R. M Nieoud (ed.), Institut National Polyteehnique de Lorraine, Naney, Pranee, p. 4-34. 

Keywords Preparative chromatography, Simulated moving bed chromatography, Continuous separation technique, Triangle theory, Bioseparation... 

When compared to the batchwise preparative chromatography, Simulated moving bed (SMB) units exhibit a number of advantages. These advantages are primarily because of the continuous nature of the operation and the efficient use of the stationary and mobile phases, which allows a decrease in desorbent requirement and an improvement of the productivity per unit time and per unit mass of stationary phase. In addition, high performances can be achieved even at rather low values of selectivity and with a relatively small number of theoretical plates. Due to these positive features, SMB is particularly attractive in the case of enantiomer separations, since it is difTicult to separate enantiomers by conventional techniques. More recent applications related to chiral technology were reported [1-3]. 

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