Phospholipid choline

Die neurological disorder associated with severe vitamin B12 deficiency is termed funicular myelitis. Vitamin B12 deficiency leads to disturbed choline-, phospholipid-, and nucleic-acid synthesis, resulting in spinal marrow damages. Disturbed myelin synthesis finally causes irreversible neurological failure. In addition, there are psychiatric disturbances (disturbed memory, apathy). [Pg.512]

De Leo, V.A., Scheide, S., Meshulam, J., Hanson, D. and Cardulla, A. (1988). Ultraviolet radiation alters choline phospholipid metabolism in human keratinocytes. J. Invest. Dermatol. 91, 303-308. [Pg.121]

Achve translocation of phospholipids aaoss the plasma membrane has been demonstrated both from the inner to the outer leaflet and from the outer to the inner leaflet. The translocation processes specifically transport phosphatidyserine and phosphatidylethanolamine from the cytoplasmic to the outer surface of the membrane while choline phosphatides are transported from the outer to the cytoplasmic surface. The rate of translocahon, in general, is greater for the amino phospholipids compared with the choline phospholipids. [Pg.46]

The maintenance of an asymmetric distribution of phospholipids across the plasma membrane with choline phospholipids predominating on the external surface and amino phospholipids confined to the cytoplasmic leaflet of the membrane has now been well estabhshed. The participation of... [Pg.54]

K. Glunde, C. Jie and Z. M. Bhujwalla, Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res., 2004, 64, 4270-4276. [Pg.160]

Hydrophobic tail Alkylbenzene sulphonate Phosphatidyl choline (phospholipids) Alkyl secondary amines... [Pg.25]

Debouzy, J. C., Fauvelle, F., Crouzy, S., Girault, L., Chapron, Y., Goschl, M., and Gadelle, A. (1997), Mechanism of a-cyclodextrin induced hemolysis 2. A study of the factors controlling the association with serine-, ethanolamine- and choline-phospholipids, /. Pharm. Sci., 87(1), 59-66. [Pg.1242]

E.O. Aboagye, Z.M. BhujwaUa, Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res. 59 (1999) 80. [Pg.346]

Zeisel, S.H. Choline and choline esters as required nutrients during pregnancy and lactation. Choline, Phospholipids, Health, and Disease S.H. Zeisel, B.F. Szuhaj, Eds. AOCS Press Champaign, IL, I998 pp.l31-142. [Pg.336]

R 316 E. Ackerstaff, K. Glunde and Z.M. Bhujwalla, Choline Phospholipid Metabolism A Target in Cancer Cells , J. Cell. Biochem., 2003,90, 525... [Pg.28]

Tumour. - A review choline phospholipid metabolism in cancer cells and tumours has been produced. ... [Pg.481]

J. A. Zirrolh, K. L. Clay, and R. C. Murphy, Tandem mass spectrometry of negative ions from choline phospholipid molecular species related to platelet activating factor. Lipids 26, 1112-1116 (1991). [Pg.448]

Jao CY, Roth M, Welti R, Salic A (2009) Metabolic labeling and direct imaging of choline phospholipids in vivo. P Natl Acad Sci USA 106(36) 15332-15337. doi 10.1073/pnas.0907864106... [Pg.27]

Edgar, G. W. F. Alkali-stable choline phospholipids ( sphingomyelin ) in tissue of amaurotic idiocies. In Cerebral Sphingolipidoses. Ed. S. M. Aronson, and B. W. Volk, p. 165. New York Academic Press 1962. [Pg.253]

The precise mechanism by which the hydrolysis of endogenous choline phospholipids takes place is unknown. The ultimate products appear to be choline, diglyceride and inorganic phosphorous. Since soybean membranes... [Pg.230]

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