Cholecystokinin structure

C-terminal octapeptide SQ 19844 Kinevac. C H N -OjjS mol wt [143.29. C 51.48%, H 5.47%, N 12.25%, O 22.39%, S 8.41%. The C-terminal octapeptide of choleeys-tokinin-pancreozymin (see cholecystokinin). Structurally similar to caerulein, q.v., it evokes a variety of biological responses similar to CCK-PZ, includiug smooth-muscle contraction of the gall bladder and small intestine, relaxation of the choledochoduodenal junction, protein secretion by the pancreas and acid secretion by the stomach. It is more active than cholecystokinin on a weight or molar basis. Initial isoln V. Mutt, J. E. Jorpes, Eur. J. Biochem. 6, 156 (1968). Prepn M. A. Ondetti et al. Get. pat. 1,922,185 corresp to U.S. pat, 3,723,406 (1969, 1970, both to Squibb) eidem, J. Am. Chem. Soc. 92, 195 (1970), Mechanical and metabolic effects K. E. Andersson ef al., Acta Physiol... 

Archer-Lahlou, E. Tikhonova, I. Escrieut, C. Dufresne, M. Seva, C. Clerc, P. Pradayrol, L. Moroder, L. Maigret, B. Fourmy, D., Modeled structure of a G-protein-coupled receptor the cholecystokinin-1 receptor, J. Med. Chem. 2005, 48, 180-191. 

Dockray GJ, Gregory RA, Hutchison JB, et al Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain. Nature 274 711-713, 1978... 

Wang HY, Friedman E Chronic lithium desensitization of autoreceptors mediating serotonin release. Psychopharmacology 94 312-314, 1988 Wang HY, Friedman E Lithium inhibition of protein kinase C activation-induced serotonin release. Psychopharmacology 99 213-218, 1989 Wank SA, Pisegna JR, de Weerth A Brain and gastrointestinal cholecystokinin receptor family structure and functional expression. Proc Natl Acad Sci USA 89 8691-8695, 1992... 

Both the stomach and the small intestine elaborate peptide hormones into the bloodstream, which is crucial in initiating food digestion. The most important hormones of this class are gastrin, secretin, and cholecystokinin. Their structures are displayed in Figure 16.13. 

Since the publication in 1986 (13,16) of the gastrin/cholecystokinin-like leucosulfakinins (LSK s), several additional insect sulfakinins have been structurally characterized (Table II). The structures of the Drosophila sulfakinins (DSK s) were deduced from a gene sequence which was isolated from Drosophila genomic DNA and head cDNA libraries (17). Although expression of the DSK s remains to be demonstrated, sulfated synthetic replicas are biologically active on the isolated cockroach hindgut (Holman, unpublished observation) as predicted by a study (18) which demonstrated that the hexamer, Tyr(S03)-Gly-His-Met-Arg-Phe-NH2, was the "core structure required for myotropic activity. 

There is a another set of problems which may occur during the construction of a cDNA library. For example, some RNAs are difficult to convert into cDNAs. This was to some extent true of AKH I, which is predicted by computer modeling to have a substantial amount of secondary structure Rat cholecystokinin mRNA also proved to be a temperamental template and the cDNA clones derived from it were short by over 100 nucleotides... 

Tokarski, J. and Hopfinger, A.J. (1994). Three-Dimensional Molecular Shape Analysis - Quantitative Structure-Activity Relationship of a Series of Cholecystokinin-A Receptor Antagonists. J.Med.Chem., 37,3639-3654. 

A 71623 is a substituted pentapeptide structure, a selective (CCKA-subtype) cholecystokinin receptor agonist. It is an... 

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