Cholecystokinin-C-terminal octapeptid

Serine-endopeptidase Cholecystokinin-C-terminal octapeptide Met3-Gly4... 

Dodd PR, Edwardson JA, Dockray GJ The depolarization-induced release of cholecystokinin C-terminal octapeptide (CCK-8) from rat synaptosomes and brain slices. Regul Pept 1 17-19, 1980... 

C-terminal octapeptide SQ 19844 Kinevac. C H N -OjjS mol wt [143.29. C 51.48%, H 5.47%, N 12.25%, O 22.39%, S 8.41%. The C-terminal octapeptide of choleeys-tokinin-pancreozymin (see cholecystokinin). Structurally similar to caerulein, q.v., it evokes a variety of biological responses similar to CCK-PZ, includiug smooth-muscle contraction of the gall bladder and small intestine, relaxation of the choledochoduodenal junction, protein secretion by the pancreas and acid secretion by the stomach. It is more active than cholecystokinin on a weight or molar basis. Initial isoln V. Mutt, J. E. Jorpes, Eur. J. Biochem. 6, 156 (1968). Prepn M. A. Ondetti et al. Get. pat. 1,922,185 corresp to U.S. pat, 3,723,406 (1969, 1970, both to Squibb) eidem, J. Am. Chem. Soc. 92, 195 (1970), Mechanical and metabolic effects K. E. Andersson ef al., Acta Physiol... 

Cholecystokinin (CCK) is one of the brain-gut peptides. Its most abundant form in the brain is the C-terminal sulphated octapeptide fragment CCK8, which interacts with the same affinity with both CCK receptor subtypes, CCK-A and CCK-B. Extensive pharmacological studies have been carried out over the last few years suggesting that CCK may participate in the neuroendocrine responses to stress (Harro et al 1993 Dauge and Lena 1998). Interestingly, CCK8 and CRH are co-locahzed in neurons of the hypothalamic PVN (Mezey etal. 1985). 

Cholecystokinin receptors are the GPCRs CCK-A and CCK-B. The C-terminal sulfated octapeptide CCK fragment (CCK8) is a major neuropeptide. CCK is involved in anorexia, cardiovascular tonus, central respiratory control, nociception, pancreatic exocrine secretion, gastric emptying, memory, vigilance and emotional states such as anxiety and panic. 

Fig. 6.1.2 Convergent enzymatic synthesis of the C-terminal cholecystokinin octapeptide (CCK-8)...

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