Chlorophenols ethyl ethers

Chloroethyl vinyl ether, 2-Chlorophenol, Cyclohexene, Dalapon-sodium. Diallate. 1,1-Dichloroethane, 2,3-Dimethylamine, Dimethylbutane, 1,4-Dioxane, Ethylamine, Ethyl ether, Erhvl sulfide. 2-Heptanone, Metaldehvde. 2-Methvlbutane. 2-Methvl-2-butene. 2-Methyl phenol, Nitromethane, 4-Nitrophenol, 2-Nitropropane, 1-Octene, 2-Pentanone, Phenol, Toluene, Triethylamine, Vinyl chloride, o-Xylene, m-Xylene Acetamide, see Acetonitrile, Acrylamide, Acrylonitrile, Ethylamine... 

Clofibrate Clofibrate, ethyl ether 2-(4-chloropheoxy)-M( -butyric acid (20.2.2), is synthesized by esterifying 2-(4-chlorophenoxy)-/yo-butyric acid (20.2.1) with ethyl alcohol. This is synthesized in a single-stage reaction from 4-chlorophenol, acetone, and chloroform in the presence of an alkali, evidently by initial formation of chlorethone-trichloro-tert-butyl alcohol, which under the reaction conditions is converted into (4-chlorophenoxy)trichloro-fert-butyl ether, and further hydrolyzed to the desired acid 20.2.1, which is further esterified with ethanol in the presence of inorganic acid [6-8]. 

Activated alumina (260 °C) column has been used for isolation of PCDEs, PCDDs, and PCDFs from chlorophenol extracts [37,38]. Four fractions were collected from an alumina column (50 g) petroleum ether (400 ml), 5% ethyl ether in petroleum ether (200 ml), 25% ethyl ether in petroleum ether (400 ml), and ethyl ether (400 ml). PCDEs, PCDDs, and PCDFs were determined in the third and fourth fractions after sulfuric acid cleanup. 

To prepare the [m-(acetylpyridinio)-n-alkyl]adenosine pyrophosphates, 10 mmoles of acetylpyridinio-n-alkylphosphoric acid and 10 mmoles of adenosine 5 -phosphoromorpholidate (as salt of 4-morpholine iV,iV -dicyclohexylcarboxamidine) are dissolved in 20 ml of freshly distilled o-chlorophenol. The mixture is stored at room temperature for 7 days. Progress of the condensation reaction is checked daily by paper electrophoresis (0.1 M Tris chloride at pH 8.1, 30 V/cm). After the reaction is completed, 60 ml of water are added to the mixture and the suspension is extracted 3 times, each with 200 ml of ethyl ether. The first ether extract obtained is reextracted with 30 ml of water. The combined aqueous phases are reduced to a volume of 5 ml under reduced pressure and are charged on to a Dowex 1X8 column (formate form, 2 X 50 cm, 100-200 mesh). The column is washed with 6.5 liters of water, and the coenzyme analogs are eluted from the resin with a convex gradient of formic acid ... 

Acetamido-4-amino-6-chloro-s-triazine, see Atrazine Acetanilide, see Aniline, Chlorobenzene, Vinclozolin Acetic acid, see Acenaphthene, Acetaldehyde, Acetic anhydride. Acetone, Acetonitrile, Acrolein, Acrylonitrile, Aldicarb. Amyl acetate, sec-Amyl acetate, Bis(2-ethylhexyl) phthalate. Butyl acetate, sec-Butyl acetate, ferf-Butyl acetate, 2-Chlorophenol, Diazinon. 2,4-Dimethylphenol, 2,4-Dinitrophenol, 2,4-Dinitrotoluene, 1,4-Dioxane, 1,2-Diphenylhydrazine, Esfenvalerate. Ethyl acetate, Flucvthrinate. Formic acid, sec-Hexyl acetate. Isopropyl acetate, Isoamyl acetate. Isobutyl acetate, Methanol. Methyl acetate. 2-Methvl-2-butene. Methyl ferf-butvl ether. Methyl cellosolve acetate. 2-Methvlphenol. Methomvl. 4-Nitrophenol, Pentachlorophenol, Phenol. Propyl acetate. 1,1,1-Trichloroethane, Vinyl acetate. Vinyl chloride Acetoacetic acid, see Mevinphos Acetone, see Acrolein. Acrylonitrile. Atrazine. Butane. 

Carbon tetrachloride. Chloroform, 2-Chlorophenol, Cyclohexanol, Cyclopentene, 1,1-Dichloroethylene, irans-l, 2-Dichloroethylene, IV.yV-Dimethylaniline, lV,lV-Dimethylformamide, 2,4-Dimethylphenol, 2,4-Dinitrotoluene, 1,4-Dioxane, 1,2-Diphenylhydrazine, Ethyl formate. Formaldehyde, Glycine, Methanol, Methylene chloride. Methyl formate, 2-Methvlphenol. Monuron, 4-Nitrophenol, Oxalic acid, Parathion, Pentachlorophenol, Phenol, l idine. Styrene, Trichloroethylene, Vinyl chloride Formylacetic acid, see cis-l,3-Dichloropropylene, irans-1,3-Dichloropropylene IV-Formylcarbamate of 1-naphthol, see Carbaryl Formyl chloride, see Chloroethane, Chloroform, sym-Dichloromethyl ether, ds-1,3-Dichloropropylene, irans-ES-Dichloropropylene, Methyl chloride. Methylene chloride. Trichloroethylene, Vinyl chloride lV-Formyl-4-chloro-o-toluidine, see Chlornhenamidine. 

Typical procedure A mixture of p-chlorophenol (128 mg, 1 mmol), NaOH (40 mg, 1 mmol) and THF (10 mL) was stirred for 10 min allyldiisobutylteUuronium bromide (360 mg, 1 mmol) was then added. The reaction mixture was stirred for another 5 h at room temperature under nitrogen. Aqueous saturated NaHCOj solution was added and extracted with CH2CI2. The extract was dried over anhydrous MgS04 and concentrated in vacuo. The residue was chromatographed on sihca gel with 95 5 hexane-ethyl acetate as eluent to give a colourless oil of allyl p-chlorophenyl ether (145 mg, 86%). 

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