Chloroformic acid, ethyl ester

Chemical Designations - Synonyms Chloroformic acid, ethyl ester Ethyl chlorocarbonate Chemical Formula CICOOC Hj... 

Chloroformic Acid, Ethyl Ester Ethyl Chloroformate... 

Azidoformic Acid Ethylester (Azidoameisen-saure-athylester, Triazoameisensaure-athyl-ester, Carbazidsaure-athylester or Stich-stoffkohlensaure-athylester in Ger), N3COOCH2CH3 mw 114.09, N 36.88% liq, bp 11.4-15°, 34°(20.5 torr), sp gr 1.1082 at 20°, nD 1.4162 at 25°. Prepd from N-aminourethane and nitric acid (Ref 2), or by reacting NaN with chloroformic acid ethyl-ester (Ref 3)... 

SYNS CHLORAiMEISENSAEUREAETHYLESTER (GERMAN) CHLOROCARBONATE D ETHYLE (FRENCH) CHLOROFORMIC ACID ETHYL ESTER ECF ETHYLCHLOORFORMIAAT (DUTCH) ETHYL CHLOROCARBONATE (DOT) ETHYLE, CHLORO-FORMIAT d (FRENCH) ETIL CLOROCARBONATO (ITALIAN) ETIL CLOROFORMIATO (ITALIAN) TL 423... 

Beilstein Handbook Reference) AI3-19852 BRN 0385653 Carbonochloridic acid, ethyl ester Cathyl chloride Chlorameisensaureathylester Chloro-carbonate d ethyle Chlorocarbonic acid ethyl ester Chloroformic acid ethyl ester Cloroformiato de etilo ECF EINECS 208-778-5 Ethoxycarbonyl chloride Ethyl carbonochloridate Ethyl chlorocarbonate Ethyl chloro-formate Ethyl chloromethanoate Ethylchloorformiaat Ethyle, chloroformiat d Ethylester kyseliny chlor-mravenoi Etil clorooarbonato Etil cloroformiato Formic xid, chloro-, ethyl ester HSDB 409 TL 423 UN1182. Liquid mp = -80.6° bp = 95° very soluble in CeHe, EtzO. CHC13. 

Chlorine peroxide 765 Chloroformic acid ethyl ester 1620... 

There is obtained from 4-[)3-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]-benzene-sulfonamide (prepared from 5-methyl-isoxazole-(3)-carboxylic acid chloride and 4-()3-aminoethyl)-benzene-sulfonamide hydrochloride, MP 213° to 214°C in pyridine) and chloroformic acid methyl ester, in a yield of 69%, the compound N-[ [-4-[)3-[5-methyl-isoxazolyl-(3)-carbox-amido] -ethyl] ] -benzene-sulfonyl] ] -methyl-urethane in the form of colorless crystals of MP 173°C. 

Ethyl chloroformate Formic acid, chloro-, ethyl ester (8) Car-bonochloridic acid, ethyl ester (9) (541-41-3)... 

ETHYL CHLOROFORMATE Cltloroformic Acid,ethyl ester, Ethyl Chlorocarbonate Flammable Liquid, I - 3 ... 

Synthesis (Kleemann et al. 1999, Janssen (Janssen), 1973 Janssen et al. (Janssen), 1973, Stokbroekx et al., 1973, Niemegeers et al., 1974) ) Treatment of 2-oxo-3,3-diphenyl-tetrahydrofuran, synthesized by treatment of diphenyl-acetic acid ethyl ester with ethylene oxide, with HBr(gas) yields bromo derivative i, which is then converted into butyryl chloride derivative ii by means of thionyl chloride in refluxing chloroform. Reaction of derivative ii with dimethylamine in toluene affords dimethyl (tetrahydro-3,3-diphenyl-2-furylidene)ammonium bromide, which is then condensed with 4-(4-chlorophenyl)-4-piperidinol by means of Na2C03 and Kl in refluxing 4-methyl-2-pentanone to provide loperamide. 

A phosgene was mixed with ethanol, then cooling by ice-water the solution of 8-chloro-l-phenyl-2,3,4,5-tetrahydro-lH-l,5-benzodiazepine-2-one in chloroform was added dropwise, mixed and allowed to stand. Then the reaction mixture was concentrated, and crystals was filtered off. So the 7-chloro-2,3,4,5-tetrahydro-4-oxo-5-phenyl-lH-l,5-benzodiazepine-l-carboxylic acid ethyl ester was obtained, melting point 172°-173°C (dec.). 

Produced from 450.5 g of 2,3,4,4a,5,6,7,8-octahydro-3-oxo-6-pyrido[4,3c]pyridazinecarboxylic acid ethyl ester and 320 g of bromine. The bromine is added dropwise to a boiling solution of the ester in 200 cc of chloroform over one hour and the mixture is stirred for another hour at the same temperature. 1 kg of ice water is added to the mixture, the chloroform portion is separated, and the acid aqueous phase is again extracted with 500 cc of chloroform. The semicrystalline crude product obtained after concentrating the chloroform phase, is recrystallized with 250 cc of absolute ethanol, melting point 165°C to 168°C (decomp.). 

The salt of (+)-5-ethyl-l,2,3,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester was dissolved in on ice, and 3 N sodium hydroxide was slowly added until the pH reached 11-12. The solution was extracted with chloroform, dried (Na2S04) and evaporated in vacuum to give (+)-5-ethyl-l,2,3,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester as a mobile oil. 

Ethyl chloroformate. Carbonochloridic acid ethyl ester... 

CHLOROFORA0C ACID ETHYL ESTER see EHK500 CHLOROFORMIC ACID 2-FLUOROETHYL ESTER see FIHIOO... 

Loratadine, U5P. Loratadine. 4-(8-chloro-5,6-dihydro-11 //-benzo[5,6I-cyclohepta 1,2-b py ridin-11 -ylidene-1 -carboxylic acid ethyl ester, is a white to off-white powder not soluble in water but very soluble in acetone, alcohols, and chloroform. 

Catalytic synthesis of l-ethyl>6-fluoro-l,4-dihydro-4-oxo-7-(l-piperazinyl)-quinoline-3-carboxylic acid ethyl ester (Norfloxacin ethyl ester) (15a). To a dry 15 mL recovery flask equipped with a reflux condenser was added 13 (150 mg, 0.5 mmole), (R)-binap (10 mg, 0.017 mmole), cesium carbonate (360 mg, 0.950 mmole), piperazine (215 mg, 2.5 mmole), Pd2(dba)3 (10 mg, 0.010 mmole), and 1.5 mL of DMF. The reaction vessel was purged with nitrogen and heated to reflux. After three hours, the reaction mixture was cooled to room temperature, and the solvent was removed under reduced pressure. The residue was purified by thin-layer chromatography on a 500 micron silica gel preparative plate with an elution mixture of chloroform methanol water ammonia (80 20 2 0.2) to give 101 mg of 15a as an off-white solid in 58% yield and, separately, 29 mg of 17 as a light brown solid in 22% yield. Using this procedure, the yield of 15a... 

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