4- Chlorobenzyl chloride

Diethyl Amino Ethyl Amine Ethyl Oxalate 2-Chlorobenzyl Chloride... 

Chlorobenzyl chloride Ambenonium chloride Ticlopidine HCI p-Chlorobenzyl chloride Clobutinol Echonazole nitrate Indomethacin Pyrrobutamine Triparanol... 

In one route, tidopidine (1) was assembled via Sn2 displacement of 2-chlorobenzyl chloride (9) with 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (8). " The nucleophile 8 was synthesized by heating 2-thiophen-2-yl-ethylamine (6) with 1,3-dioxolane in the presence of concentrated hydrochloric acid. 1,3-Dioxolone gave better yields than with formaldehyde, paraformaldehyde and 1,3,5-ttioxane. The interesting transformation 6 —> 8 first involved the formation of the corresponding Mannich base 7, which then underwent a Pictet-Spengler type reaction to afford the ring-closure product 8. It was of interest to note that a possible intramolecular aminomethylation did not take place. 

Another route toward ticlopidine (1) involved an Sn2 displacement of 2-chlorobenzyl chloride (9) by thieno[3,2-c]pyndine (10) to produce thieno[3,2-c]pyridinium chloride 11. Subsequent reduction of the pyridinium salt (11) using NaBH4 then delivered ticlopidine (1). ... 

N,N -Bis(2-Diethylaminoethyl)Oxamide Bis(2-Chlorobenzochloride) A solution of 7 grams (0.025 mol) of N,N -bis(2-diethylaminoethyl)oxamide and 16.1 grams (0.1 mol) of 2-chlorobenzyl chloride in 100 ml of acetonitrile was refluxed for eleven hours. The solid which separated upon cooling was collected by filtration and recrystallized by dissolving it in ethanol and adding ether to cause the product to separate. After drying at about 60°C (1-3 mm) there was obtained 4.1 grams of N,N -bis(2-diethylaminoethyl)oxamide bis(2-chlorobenzochloride), MP 196-199°C. 

The chlorination of benzyl chloride over H-K-L, K-L, K-beta, K-mordenite, K-ZSM-5, K-Y, and K-X, and in the absence of catalyst, at 353 K produces a mixture of 2-chlorobenzyl chloride (2-CIBC), 3-chlorobenzyl chloride (3-CIBC),... 

Beilstein Handbook Reference) AI3-14885 Benzene, 1-chloro-2-(chloromethyl)- BRN 0471700 1-Chloro-2-(chloromethyl)benzene 2-Chlorobenzyl chloride a,2-Dichlorotoluene a,o-Dichlorotoluene EINECS 210-258-8 NSC 8446 o-Chlorobenzyl chloride Ortho-a-dichlorotoluene Toluene, a,o-dichloro- Toluene, o,a-dichloro-. Liquid mp = -17° bp = 217° d° = 1.2699 Am = 271, 278 nm (s = 339, 263, MeOH) insoluble in H2O, slightly soluble in EtOH, CCU, soluble in CS2, very soluble in Et20, CeHe, AcOH,... 

One representative synthesis of prothioconazole starts [95] with the addition of the Grignard derivative of 2-chlorobenzyl chloride on the carbonyl double bond of chloromethyl 1-chloro-cyclopropyl ketone (Scheme 17.19). The untouched chlorine atom of the chloromethyl group is then classically substituted with 1,2,4-triazole. From this intermediate, one way to obtain the 2,4-dihydro-3H-l,2,4-triazole-3-thione of prothioconazole is by direct lithiation of the 1,2,4-triazole at position 5 with n-butyl lithium and reaction with sulfur. The commercially available compound is a mixture of two enantiomers (chirality of the quaternary carbon bearing the hydroxy group). 

Chlorobenzyl chloride 1950 2-Chloro-/>-phenylenediamine 1876 Citronellol acetate 4199... 

Chlorobenzyl chloride (l-Chloro-2-(chloromethyl)benzene) (Chlorobromomethane) see Bromochloromethane (2-Chloro-1,3-butadiene) see Chloroprene (1-Chlorobutane) see n-Butylchloride (l-Chloro-2-(chloromethyl)benzene) see 2-Chlorobenzyl chloride 611-19-8 C Sensitizatii... 

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