A Representative Synthesis

Thus although 2 substituted quinolines have been reduced to chiral 1,2,3,4 tetrahydroquinolines with good enantioselectivity, there remains considerable prog ress to be made in this area. Some 2 substituted quinolines can be hydrogenated in 95% ee, but others, such as 2 phenylquinoline, give considerably lower values. More important, none of the catalyst systems that hydrogenate quinolines highly 

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Type A1 — Z X Z-t—A1 Synthesis. Disazo dyes of this type are produced from coupling twice to dye intermediates such as those shown in Fig. 13.99, and are largely direct dyes for cotton. A representative synthesis is shown in... 

A representative synthesis of the dihydrocinnamic acid ester (shown in Scheme B) begins with the bromination of vanillin (8). 

A Representative Synthesis It would be inappropriate, and near impossi ble, to review asymmetric imine hydrogenation without discussing (S) metolachlor. A great deal of progress in the iridium catalyzed asymmetric hydrogenation of imines has been inspired by the industrial synthesis of (S) metolachlor and by the extremely well documented development of this synthesis [28 30]. The key step in the commercial synthesis of (S) metolachlor is the hydrogenation of MEA imine, E (Scheme 6.2) [67]. 

Cyclopentenones. Japanese chemists have reported a new synthesis of substituted cyclopentenones involving a Wittig reaction of the anion of an a-dike-tone with vinyl triphenylphosphonium salts. A representative synthesis is for-... 

A pH ranging from 8-10, a temperature of 303-353K. low concentrations of reagents and a low flow of the streams arc most commonly used. A representative synthesis of NiAI-HT is mentioned below ... 

Cycloalkanes. Whitesides and Gutowski have described a synthesis of cycloalkanes involving reaction of oi,wGrignard reagents with this Ag(I) salt, which is definitely superior in this case to tetrakis[iodo(tri- -butylphosphine)-silver(I)]. A representative synthesis is outlined in equation (I). The method is... 

Macrocyclic phosphonates have been reported as kinase inhibitors (P12WO074951). In a representative synthesis, 4-chloropyrimidine 31 was reacted with the aminoisoindolone 32 leading to the 2,4-diaminopyrimidine 33 in 79% yield (Scheme 7). Selective monodeprotection of phosphonate followed by coupling using PyBOP in h h dilution conditions afforded... 

JMC2196, 14JMC8293). This procedure offers an easy tuning of aryl substituents directly bound to the phosphorus atom. The reaction proceeds with rather low control of stereoselectivity on the adjacent phosphorus and carbon centers. In a representative synthesis, illustrated in Scheme 8, four diastereomers 40a—d were obtained in almost the same ratio. The main ones 40a and 40b can be considered, respectively, as the analogs of glucose and mannose. They were isolated by selective crystallization. 

We use the environment shown in Figure 6 as a representative synthesis framework to show the utility of BIF. The figure is organized into three columns the synthesis tasks on the left, the user interface on the right, and different design views of the intermediate representation in the middle the state table, the unit list, the connectivity list, and the symbol list. 

The polyphenylquinoxalines (PPQs) are similar to the PQs but offer better solubility, processability, and thermooxidative stability. These polymers are prepared from the reaction of aromatic few(o-diamines) and bis(pheny -a-diketones) as first reported in 1967. Since their initial disclosure, extensive work has been reported on the chemistry, mechanical, and physical properties of PPQs. A representative synthesis shown in Eq. (3) involves the reaction of 3,3, 4,4 -tetraaminobiphenyl and 4,4 -oxy w(benzil) ... 

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