3- Chlorobenzene sulfonamide

Chlorobenzaldehyde Chlormezanone Chlorobenzene Methixene HCI p-Chlorobenzene sulfonamide Chlorpropamide... 

Combined treatment is necessary in the long-term treatment of essential hypertension. (3-Blocker and diuretic properties in a same molecule would present a great interest for hypertension management. Few attempts to synthesize hybrid molecules by combining the structures of a (3-adrenorecep-tor antagonist and a diuretic were described (Figure 18.35). A hybrid sulfonamide was achieved by linking the (3-blocker propranolol derivative with the 2-chlorobenzene sulfonamide moiety of mefruside. ... 

The best known example of anti-resistant compounds of the benzene sulfonamide type is N,N-di-/i-butyl-4-chlorobenzene sulfonamide (15), introduced under the name WARF anti-resistant (Fales and Bodenstein, 1961 Pittai et al ... 

During the iodination with the oxidizer chloramine T, all reactants are present in solution (one-phase system). Pierce offers oxidizers that were applied to a solid phase (two-phase system iodobeads, iodogen). lodobeads are N-chlorobenzene sulfonamides attached to polystyrene beads. Iodogen is a hydrophobic chloramine T derivative applied to the wall of the reaction vessel. After the reaction with iodobeads and iodogen, the solid phase with the oxidizer can easily be separated from the reaction mixture. Hence, the addition of reducing agent (bisulfite) is unnecessary, which spares the sensitive disulfide bridges of some proteins. In addition, N-chlorobenzene sulfonamide is a milder oxidizer than chloramine T. 

Photolytic. The reported photolysis half-lives of chlorsulfuron in distilled water, methanol and natural creek water at X >290 nm were 18, 92 and 18 hours, respectively. In all cases, 2-chlorobenzene sulfonamide, 2-methoxy-4-methyl-6-amino-l,3,5-triazine and trace amounts of the tentatively identified compound nitroso-2-chlorophenylsulfone formed as photoproducts (Herrmann et al., 1985). 

When the product of reacting chlorobenzene and chlorosulfonic acid is aminated under pressure, the product is dapsone (32), used in control of leprosy75. This sulfone was developed as a result of sulfonamide studies undertaken at Bayer that include thiosemi-carbazones active against tuberculosis. 

Only the benzo analog of this bicyclic structure is known, in the form of its S, S -dioxide (296). It is formed as a main product of thermal cyclization of pyrazole (295) in chlorobenzene (isolated yield of 23%) together with 8% of the corresponding sulfonamide (297) (Equation (39)) <80JCS(Pl)982>. 

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