1- Chloro-l-nitropropane

Although slightly less than an equivalent amount of potassium hydroxide is used, the last of the 1-chloro-l-nitropropane dissolves slowly, and the pH drops sufficiently to allow rapid reaction only after a variable (usually about 3 hours) period of standing. The reaction may also be started by heating one spot on the container with a jet of steam, but it is more convenient and reliable to initiate reaction by cautious addition of acid in the manner described. 

The 1-chloro-l-nitropropane used was the commercial grade obtained from Commercial Solvents Corporation. The yield was unchanged when a distilled sample, b.p. 143°, was used. 

The action of a sodium bicarbonate solution or a 10% sodium hydroxide solution on 1-chloro-l-nitropropane will produce 3,4-dinitro-3-hexene. The procedure described here is a modification of that described by Nygaard and Noland.3... 

Chloromethyl) oxhane, see Epichlorohydrin 2-(Chloromethyl)oxirane, see Epichlorohydrin 4-Chloro-3-methylphenol, see p-Chloro-ro-cresol p-Chloro-3-methylphenol, see p-Chloro-ro-cresol Chloromethyl phenyl ketone, see a-Chloroacetophenone p-Chloronaphthalene, see 2-Chloronaphthalene 4-Chloronitrobenzene, see p-Chloronitrobenzene l-Chloro-4-nitrobenzene, see p-Chloronitrobenzene 4-Chloro-l-nitrobenzene, seep-Chloronitrobenzene p-Chloro-1-nitrobenzene, see p-Chloronitrobenzene Chloronitroform, see Chloropicrin Chloronitropropane, see 1-Chloro-l-nitropropane Chlorophen, see Pentachlorophenol... 

Nitro-l,l -biphenyl, see 4-Nitrobiphenyl p-Nitrobiphenyl, see 4-Nitrobiphenyl Nitrocarbol, see Nitromethane 4-Nitrochlorobenzene, see p Chloronitrobenzene p-Nitrochlorobenzene, see p Chloronitrobenzene Nitrochloroform, see Chloropicrin Nitrochloropropane, see 1-Chloro-l-nitropropane... 

Nitro-2-cliloropropane, see 1-Chloro-l-nitropropane 4-Nitrodiphenyl, see 4-Nitrobiphenyl... 

The addition of a-chloronitroalkanes to solutions of alkali metal hydroxide has been used for the synthesis of some 1,2-dinitroethylene derivatives (43)." " These reactions involve attack of the nitronate salt (40) on the aci-form (39) of the unreacted em-chloronitroalkane followed by formal loss of hydrogen chloride. 2,3-Dinitro-2-butene and 3,4-dinitro-3-hexene (45) are formed in this way from 1-chloro-l-nitroethane and 1-chloro-l-nitropropane (44) respectively. 

Toxieology. 1-Chloro-l-nitropropane is an irritant of the eyes and mucous membranes. It is a pulmonary irritant in animals, and severe exposure is expected to cause the same effect in humans. 

Chloro-l-nitropropane was mutagenic in Salmonella assays both with and without activation. 

The 2003 ACGIH threshold limit value-time-weighted average (TLV-TWA) for 1-chloro-l-nitropropane is 2 ppm (lOmg/m ). 

S211 1-Chloro-l-nitropropane 100 Chromosorb 108 Ethyl acetate GC/FID 51-206... 

Condensation, of benzyl cyanide and benzophenone, 31, 52 of carbon tetrachloride with phosphorus trichloride, 37, 82 of 1-chloro-l-nitropropane by alkali, 37, 23... 

OTHER COMMENTS it should be noted that this chemical, 1-chloro-l-nitropropane, should be furnished for lab use only. This material may not be used as drugs, cosmetics, food additives, agricultural products, pesticidal products, and as household chemicals. 

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