Chloro-1-nitropropane

Furthermore, when CMME is hydrolyzed, HCl and formaldehyde are produced, which may recombine to form BCME. Therefore, although findings may reflect the carcinogenicity of BCME, commercial-grade CMME also must be considered to be a carcinogen, but perhaps of a lower potency than that of BCME. 

CMME is a mucous membrane and respiratory irritant in both humans and animals. Acute exposure of rats and hamsters resulted in pulmonary edema and hemorrhage and necrotizing bronchitis. Human exposure to CMME has been reported to cause breathing difficulties, sore throat, fever, and chills. An increased frequency of chronic cough and low-end expiratory flow rates has been observed in a dose-related fashion with exposure to CMME and BCME.  

Technical-grade CMME (contaminated with BCME), on subcutaneous injection in mice, has produced local sarcomas. Dermal application of mice, followed by a phorbol ester promoter, resulted in an apparent excess of skin papillomas and carcinomas. Inhalation studies in mice showed an equivocally increased occurrence of lung tumors compared with unexposed controls.  

The lARC has concluded that there is sufficient evidence for carcinogenicity of technical-grade CMME to both humans and animals.  

ACGIH has designated chloromethyl methyl ether as an A2-suspected human carcinogen a numerical threshold limit value is not recommended. 

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Chloro-1 -nitropropane Chloroacetaldehyde a-Chloroacetophenone Chlorobenzene (monochlorobenzene) o-Chlorobenzylidine malononitrile Chlorobromomethane Chlorodiphenyl (42% chlorine) Chlorodiphenyl (54% chlorine) 2-Chloroethanol (ethylene chlorohydrin) Chloroform... 

Chloro-4-nitrobenzene 1 -Chloro-1 -nitropropane Chloropentafluoroethane Chloropicrin(<> fl-Chloroprene"1 ... 

IR spectra in Ref 2. Prepd by reacting EtCiCEt with N204 in ether (Ref 3). Reacting 1-chloro-1-nitropropane with aq KOH and then acidifying to a pH of 9. The residue after separation and washing is distilled, under vac nitrogen atmos to prevent explosion, to get additional product (Ref 4)... 

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