Chloro-3,5-dimethylphenol

The halogenating agent was added to 2,6-dimethyl phenol in dichloromethhane and the mixture stirred at ambient temp, for 1 min. to give 4-chloro-2,6-dimethylphenol... 

Chloro-2,6-dimethylphenol CgHgCIO 1124-06-7 166.609 silv-grrr rrd dig) 74.6 si HgO vs bz, Eton, peth... 

Sulfuric acid was initially thought to be the reagent to promote the Pechmann reaction to yield coumarins. However, it was subsequently found to provide in some cases good yields of the chromone. For example, reaction of chloro-dimethylphenol 31 with ethyl acetoacetate 6 with cone. H2SO4 gave a 35% yield of 32. ... 

Examples of palladium-catalyzed reduction are 4-chloro-2,6-di-r-butyl-phenol to 2,6-di-t-butylcyclohexanone (750 psig, 25 C) with loss of halogen 24), 1,8-dihydroxynaphthalene to 8-hydroxy-1-tetralone 30), and 2,4-dimethylphenol to 2,4-dimethylcyclohexanone (27). 

Therapeutic Function Topical antiseptic and disinfectant Chemical Name 4-Chloro-3,5-dimethylphenol Common Name —... 

Phenol 2,4,6-trichlorophenol p-chloro-m-cresol 2-chlorophe-nol 2,4-dichlorophenol 2,4,-dimethylphenol 2-nitrophenol 4-nitrophenol 2,4-dinitrophenol and pentachlorophenol... 

Many derivatives of phenol are now made by a synthetic process. Homologous series of substituted derivatives have been prepared and tested for antimicrobial activity. A combination of alkyl substitution and halogenation has produced useful derivatives including clorinated phenols which are constituents of a number of proprietary disinfectants. Two ofthe most widely used derivatives are/ -chloro-m-cresol (4-chloro-3-methylphenol, chlorocresol, Fig. 10.7C) which is mostly employed as a preservative at a concentration of 0.1%, and / -chloro-m-xylenol (4-chloro-3,5-dimethylphenol, chloroxylenol. Fig. 10.7C) which is used for skin disinfection, although less than formerly. Chloroxylenol is sparingly soluble in water and must be solubihzed, for example in a suitable soap solution in conjunction with terpineol or pine oil. Its antimicrobial capacity is weak and is reduced by the presence of organic matter. 

Acetamido-4-amino-6-chloro-s-triazine, see Atrazine Acetanilide, see Aniline, Chlorobenzene, Vinclozolin Acetic acid, see Acenaphthene, Acetaldehyde, Acetic anhydride. Acetone, Acetonitrile, Acrolein, Acrylonitrile, Aldicarb. Amyl acetate, sec-Amyl acetate, Bis(2-ethylhexyl) phthalate. Butyl acetate, sec-Butyl acetate, ferf-Butyl acetate, 2-Chlorophenol, Diazinon. 2,4-Dimethylphenol, 2,4-Dinitrophenol, 2,4-Dinitrotoluene, 1,4-Dioxane, 1,2-Diphenylhydrazine, Esfenvalerate. Ethyl acetate, Flucvthrinate. Formic acid, sec-Hexyl acetate. Isopropyl acetate, Isoamyl acetate. Isobutyl acetate, Methanol. Methyl acetate. 2-Methvl-2-butene. Methyl ferf-butvl ether. Methyl cellosolve acetate. 2-Methvlphenol. Methomvl. 4-Nitrophenol, Pentachlorophenol, Phenol. Propyl acetate. 1,1,1-Trichloroethane, Vinyl acetate. Vinyl chloride Acetoacetic acid, see Mevinphos Acetone, see Acrolein. Acrylonitrile. Atrazine. Butane. 

Carbon tetrachloride. Chloroform, 2-Chlorophenol, Cyclohexanol, Cyclopentene, 1,1-Dichloroethylene, irans-l, 2-Dichloroethylene, IV.yV-Dimethylaniline, lV,lV-Dimethylformamide, 2,4-Dimethylphenol, 2,4-Dinitrotoluene, 1,4-Dioxane, 1,2-Diphenylhydrazine, Ethyl formate. Formaldehyde, Glycine, Methanol, Methylene chloride. Methyl formate, 2-Methvlphenol. Monuron, 4-Nitrophenol, Oxalic acid, Parathion, Pentachlorophenol, Phenol, l idine. Styrene, Trichloroethylene, Vinyl chloride Formylacetic acid, see cis-l,3-Dichloropropylene, irans-1,3-Dichloropropylene IV-Formylcarbamate of 1-naphthol, see Carbaryl Formyl chloride, see Chloroethane, Chloroform, sym-Dichloromethyl ether, ds-1,3-Dichloropropylene, irans-ES-Dichloropropylene, Methyl chloride. Methylene chloride. Trichloroethylene, Vinyl chloride lV-Formyl-4-chloro-o-toluidine, see Chlornhenamidine. 

Chloro-3,5-dimethylphenol [88-04-0] M 156.6, m 115.5 . Crystd from benzene or toluene. 

In the former case the diphenoquinone is formed exclusively while in the latter case small amounts of low molecular weight polymer have been observed. As would be expected, substituents which raise the oxidation potential of the phenol retard the polymerization. Thus whereas 2.6-dimethylphenol polymerizes readily at room temperature, temperatures in the neighborhood of 60° C are required to polymerize 2-chloro-6-methylphenol at comparable rates and even higher temperatures are necessary to oxidize 2.6-dichlorophenol. 

Xylenol is an important starting material for insecticides, xylenol—formaldehyde resins, disinfectants, wood preservatives, and for synthesis of a-tocopherol (vitamin E) (258) and x//-CC-tocopherol acetate (USP 34-50/kg, October 1994). The Bayer insecticide Methiocarb is manufactured by reaction of 3,5-xylenol with methylsulfenyl chloride to yield 4-methylmercapto-3,5-xylenol, followed by reaction with methyl isocyanate (257). Disinfectants and preservatives are produced by chlorination to 4-chloro- and 2,4-dichloro-3,5-dimethylphenol (251). 

FIGURE 13.14 A typical LC-MS chromatogram obtained in the scan mode of a preconcentrated aqueous standard solution (a) and of a preconcentrated spiked river water sample (b), as well as of an unspiked preconcentrated river water sample (c). Peak labels denote Ph, Phenol 2,4-DMP, 2,4-dimethylphenol 2-CP, 2-chlo-rophenol 4-CR,4-chlorophenol 4-NP,4-nitrophenol 2-NP,2-nitrophenol 4-C-3-MP,4-chloro-3-methylphenol 2,4-DCP, 2,4-dichlorophenol 2,4-DNP, 2,4-dinitrophenol 2,4,6-TCP, 2,4,6-trichlorophenol 2-M-4.6-DNP, 2-methyl-4,6-dinitrophenol and PCP, pentachlorophenol. Spike level 1 pg/L 10 mL preconcentrated. 

Pd-catalyzed CO- bond forming reactions were performed by Buchwald [8] et al. with 2-dimethylamino-2 -di-(tert.-butyl)-biphenyl as ligand. 3,4-Dimethylphenol can be arylated smoothly with 2-chloro-4-methyl-toluene in the presence of sodium hydride [eq. (f)]. 

Dimercaptotoluene(DMT) 3,4-dithiotoluene Hexachlorobenzene 50 ng/ml (ng/microliter) in dichloromethane Test mixture solution containing 12.5 40 p.g ml-1 (microgram per milliliter) each in dichloromethane of Trimethylphosphate 2,6-Dimethylphenol 5-Chloro-2-methylaniline Tri-n-butylphosphate 1ml 5-g 2ml 2ml... 

A column performance test is used to ensure the proper condition of columns and the stability of retention parameters. Because CWC-related chemicals greatly differ both chemically and physically from each other, the test chemicals have been selected so that their physical, chemical, and retention properties are different, and so that they elute evenly over the whole chromatogram. The use of the following chemicals in a column performance test is recommended trimethylphosphate, 2,6-dimethylphenol, 5-chloro-2-methylaniline, tri-n-butylphosphate, dibenzothiophene, malathion, and methyl stearate. The concentration of test chemicals depends on the sensitivity of detectors. The... 

A key factor in the QA program is the performance control of the instrumentation. A number of test compounds have been recommended for checking the performance of a GC/MS instrument for the analysis of scheduled chemicals (34). These include DMMP, DMMP-rf9, trimethylphosphate, 2,6-dimethylphenol, 5-chloro-2-methylaniline, tri-n-butylphosphate, dibenzothiophene, malathion, and methyl stearate. DMMP is a moderately polar compound and is considered to be a good test compound for checking the GC performance. The deuterated form is recommended because it does not give cross-contamination in the analysis of authentic samples. However, because no scheduled chemicals can be brought on-site during an inspection, the use of DMMP-<79 has been replaced by trimethylphosphate for on-site analysis. The correctness of the intensity ratios in the El mass spectra can be verified by means of the test compounds with the different isotopic peaks 5-chloro-2-methylaniline... 

Synonyms. Parachlorometaxylenol PCMX. Proprietary Names. Dettol Metasep. 4-Chloro-3,5-dimethylphenol C8H9C10= 156.6 CAS—88-04-0... 

DIMETHYLHYDRAZINO)ACRIDINE see CGH800 4-CHLORO-3,5-DIMETHYLPHENOL see CLWOOO ((4-CHLORO-6-((2,3-DIMETHYLPHENYL)AMINO)-2-PYRIMIDINYL)THIO)ACETIC ACID see CLW250... 

Fig. 32.5 Influence of GC column internal diameter on separation 1. phenol 2. 2-chlorophenol 3. 2-nitrophenol 4. 2,4-dimethylphenol 5. 2,4-dichlorophenol 6. 4-chloro-3-methylphenol 7. 2,4,6-trichlorophenol 8. 2,4-dinitrophenol 9. 4-nitrophenol 10. 2-methyl-4,6-dinitrophenol 11. pentachlorophenol.

The extent of C-alkylation as a side reaction in etherification varies about 1% of allyl 2-allylphenyl ether is formed when phenol is used in the acetone and potassium carbonate method with allyl bromide with cinnamyl bromide or 7,7-dimethylallyl bromide the extent of C-alkylation is greater. A complicated mixture of C- and 0-alkylation products results from the treatment of phenol with 4-bromo-2-hexene and 4-chloro-2-hexene. 4-Hexenylresorcinol has been obtained in about 40% yield from the reaction of I-bromo-2-hexene, resorcinol, and potassium carbonate in boiling acetone. An appreciable amoimt of C-allQrlation occurs when 2,6-dimethylphenol is treated with allyl bromide and sodium ethoxide in ethanol. Since, in general, the ampunt of C-alkjda-tion is greatly increased by carrying out the alkylation on the sodium salt of the phenol in benzene, this method is unsuitable for the preparation of allyl aryl ethers. 

Chloro-3,5-dimethylphenol Nipacide PX parachlorometax-ylenol p-chloro-m-xylenol PCMX. 

The crystal structures of many o- and p-chlorophenols, but only of a few m-chloro-phenols, are known. Representative examples are l,5-dichloro-2,6-dihydroxynaphthalene (45), a complex between 3,5-dichlorophenol (46) and 2,6-dimethylphenol , and a complex of p-chlorophenol (47) with 1,4-phenylenediamine. The C—OH bond lengths in 45 and 47 are normal (1.364 and 1.361 A, respectively). The same bond in 46 is significantly longer (1.387 A) for unknown reasons. 

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