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Chlorguanide

Different antimalarials selectively kill the parasite s different developmental forms. The mechanism of action is known for some of them pyrimethamine and dapsone inhibit dihydrofolate reductase (p. 273), as does chlorguanide (proguanil) via its active metabolite. The sulfonamide sulfadoxine inhibits synthesis of dihydrofolic acid (p. 272). Chlo-roquine and quinine accumulate within the acidic vacuoles of blood schizonts and inhibit polymerization of heme, the latter substance being toxic for the schizonts. [Pg.294]

Sporonticides. Agents such as chlorguanide and pyrimethamine help to eradicate the disease by preventing sporogony and multiplication of the aforementioned parasites. [Pg.248]

Pyrimethamine is a fohc acid antagonist (antifol) with pharmacological actions similar to chlorguanide, methotrexate, and trimethoprim. Pyrimethamine may be used in combination with sulfadoxine for suppression and sulfadiazine for treatment of chloroquine-resistant Plasmodium falciparum. [Pg.250]

Partovian C, Jacqz-Aigrain E, Keundjian A, et al. Comparison of chlorguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans. Clin Pharmacol Ther 1995 58 257-263. [Pg.634]

SYNS BIGUMAL CHLORGUANIDE CHLOROGUANIDE PALUDRINE PROGUANIL... [Pg.345]

A novel structural type (5) was reported to have potent activity against resistant malaria strains. Minor modifications, including removal of the N-OH substituent eliminated activity.Limited clinical pharmacology, biochemistry and mode of action studies are available in the entire parasitology area. Two recent papers report the pharmacokinetics of amodiaquine, chlorguanide, chloraquine, pyrimethamine, quinine and sulfadoxine. [Pg.123]

Biguanides — Chlorguanide (Proguanil and Paludrine) has suppressive as well as prophylactic actions. [Pg.663]

A. Proguanil Hydrochloride BAN, Proguanil INN, Chlorguanide Hydrochloride USAN,... [Pg.638]

British scientists during World War II had adopted an altogether different line of action in breaking away from the normal quinoline and acridine types of structure, and eventually paved the way in the epoch making discovery of the biguanide, chlorguanide. [Pg.640]

See other pages where Chlorguanide is mentioned: [Pg.194]    [Pg.194]    [Pg.271]    [Pg.274]    [Pg.115]    [Pg.264]    [Pg.234]    [Pg.143]    [Pg.1720]    [Pg.134]    [Pg.478]    [Pg.1582]    [Pg.587]    [Pg.587]    [Pg.194]    [Pg.194]    [Pg.294]    [Pg.250]    [Pg.1572]    [Pg.1043]    [Pg.134]    [Pg.134]    [Pg.80]    [Pg.283]    [Pg.425]    [Pg.143]    [Pg.638]    [Pg.276]    [Pg.243]    [Pg.243]    [Pg.243]    [Pg.260]    [Pg.264]   
See also in sourсe #XX -- [ Pg.115 ]

See also in sourсe #XX -- [ Pg.294 ]

See also in sourсe #XX -- [ Pg.115 ]

See also in sourсe #XX -- [ Pg.587 ]

See also in sourсe #XX -- [ Pg.1720 ]

See also in sourсe #XX -- [ Pg.294 ]

See also in sourсe #XX -- [ Pg.123 ]

See also in sourсe #XX -- [ Pg.276 ]

See also in sourсe #XX -- [ Pg.89 , Pg.204 , Pg.369 ]



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Chlorguanide hydrochloride

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