Chloramine-7 , estimation

Both chloramine-T and dichloramine-T can be readily estimated, because they liberate iodine from potassium iodide quantitatively in the presence of... 

Work in the preceding 10 years had however been simplified by the development by P.P.Cohen of a new, specific micromethod for the estimation of glutamate, following a suggestion of Krebs. Glutamic acid specifically reacts with chloramine—T, an active form of hypochlorite, to give succinonitrile and carbon dioxide which could be measured manometrically. 

In Eq. (18.2), the reaction rate for chloramine (NH2CI ) formation is rapid relative to the formation of hydrazine in Eq. (18.3). In this step dilute ammonia solution (5% to 15%) is added to the NaOCl at a ratio of 3 1. Use of NaOCl is estimated to be 3.5 pounds per pound of hydrazine. 

The Bayer Ketazine process is based on the reaction of chloramine with ammonia in the presence of acetone at pH 12 to 14. NaOCl, acetone and a 20% aqueous solution of ammonia (at a mole ratio of 1 2 20, respectively) are fed to a reactor at 35°C and 200 kPa to make the aqueous dimethyl ketazine solution. Excess ammonia and acetone are removed in a series of columns and recycled to the reactor. The ketazine solution is distilled to make a hydrazine hydrate containing 64% hydrazine. A sketch of this process is shown in Figure 18.4132. Use of NaOCl is estimated to be 3.5 pounds per pound of hydrazine. 

Common strong oxidants are used to obtain colored products by acting directly on the pharmaceutical, e.g., Ce(IV), Cr(VI), metavanadate, BrOT, N-bromosuccinimide, and chloramine-T. Direct oxidation of imipramine and desipramine by ammonium metavanadate allows its determination in pharmaceutical dosage forms. The quantitative estimation of 11 phenothiazine drugs in dosage forms is also based on the interaction of these phenothiazine compounds with diphenylamine in presence of N-bromosuccini-mide and sulfuric acid. Most of the studied phe-nothiazines yield bluish green products and the color is stable for at least 1 h. 

The use of chloramine-T, which acts as a hypochlorite in solution and yet is far more stable, is the basis of a method for estimating nitrites by van Eck. ... 

If the amount of sugar oxidised varies much from the above specified quantities, the factor used differs a little. Sucrose is attacked slightly and allowance must be made in estimating lactose or glucose if this be present (estimating it independently either by chloramine after inversion, or by other means). A table of sucrose corrections, i.e, ml of 0 05N thiosulphate to be deducted for grammes of sucrose present in the titration solution, is given in Appendix XIX. 

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