Chloral hydrate nervous system

Synergy of unwanted pharmacological effect ginseng and its products will inhibit the central nervous system (CNS) when they are applied with luminal, chloral hydrate, or ephedrine, which can increase the release of dopamine, noradrenaline, and serotonin in the CNS thus inducing a hypertensive crisis if monoamine oxidase inhibitors (MAOIs) are given simultaneously. 

The effects of chloral hydrate vary with different individuals but, as a rule, a dose of 20 grains acts in a healthy subject as a mild sedative of the sensory nervous system, and produces, about half or three quarters of an hour after it has been taken, a light, Tefreshing, and normal sleep, without causing headache or disturbance of the respiration and pulse. 

Chloral hydrate is a central nervous system (CNS) depressant. It is probably responsible for early depressant effects, but prolonged CNS depression is largely due to trichloroethanol. The mechanism by which chloral hydrate and trichloroethanol depress the CNS is not completely known. 

Haloaldehydes and haloketones have received very little attention. Members of this class have been identified as key metabolites of chemicals such as TCE, vinyl chloride, and dibromochloropropane. Trichloroacetaldehyde and chloral hydrate are important compounds of this group. Chloral hydrate is primarily known for its depressant effects on the central nervous system and doses of 500-2000 mg produce central nervous system depression in humans. It is also known to cause liver damage. This compound is classified as group 3 by lARC. TCA and DCA are major metabolites of chloral hydrate. 

Nervous system In a comparison of the effects of single doses of melatonin 2-6 mg and chloral hydrate on sleep electroencephalography in a randomized study of 348 children aged 1 month to 6 years, melatonin was well tolerated and associated with less drowsiness than chloral hydrate [48 ]. Two of those who took melatonin developed diarrhea and two developed agitation, but there was insufficient information to assess causality. 

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