ChirBase Chiral Applications

Figure 10-5. The 2005 version of the ChirBase LC chiral applications database contains over 100,000 entries.

The main applications of enantiomeric separation by GC concern precise determination of enantiomeric composition of chiral research chemicals, drugs, intermediates, metabolites, pesticides, flavors and fragrances, etc. CHIRBASE, a database of chiral compounds, provides comprehensive structural, experimental, and bibliographic information on successful and unsuccessful chiral separations, and rule sets for each CSP and information about the processes of chiral separations. According to CHIRBASE, an appropriate CSP is available for almost every racemic mixture of compounds ranging form apolar to polar. Some 22,000 separations of enantiomers, involving 5,500 basic chiral compounds and documented in 2,200 publications, have been achieved by GC. This method is particularly suitable for volatile compounds such as inhalation anesthetic agents, e.g., enflurane, isoflurane, desflurane, and racemic a-ionone. 

Roussel C, Pierrot-Sanders J, Heitmann I, Piras P. CHIRBASE database current stams and derived research applications using molecular similarity, decision tree and 3D enantiophore search. In Subramanian G, editor. Chiral Separation Techniques. A practical Approach. 2nd edition. Weinheim Wiley-VCH 2001. p 95-125. 

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