Chiniofon sodium

Leipert s method for determination of iodide is widely used, especially on solutions derived from the combustion of organic compounds containing iodine. This method depends upon the oxidation of iodide to iodate with bromine water, removal of the excess bromine by addition of some suitable reagent (phenol is widely used—see under Chiniofon Sodium, p. 315—but formic acid is most convenient), addition of iodide and titration of the liberated iodine with thiosulphate. The method has the great advantage that it gives a six-fold increase in the quantity of iodine to be titrated. A detailed procedure for its application will be found in Appendix IV, p. 800. 

The official method for the determination of iodine in this ointment is the alkaline-fusion method given under Chiniofon Sodium, using 0-5 g. 

Strong Ointment of Iodine, B.Vet.C. Prepared to contain 10 per cent of iodine and 7 5 per cent of potassium iodide in a wool fat and paraffin base. The total iodine content is determined by the method given under Chiniofon Sodium, using 1 g. 

Tablets of Chiniofon Sodium, B.P. Usually contain 0-25 g in each tablet.

The tablets are assayed as Chiniofon Sodium using an amount of powdered tablets equivalent to about 0 2 g of Chiniofon Sodium. 

This is 8-hydroxy-5,7-di-iodoquinoline. The easiest method of assay is by the flask-combustion technique, using about 12 mg, 1 ml 0-02N thiosulphate = 0-0006616 g C9H5ONI2. It can also be determined by the general alkali-fusion method for organically combined iodine given under Chiniofon Sodium using 0-1 g of sample, 1 ml 0-lN thiosulphate = 0-003308 g. The U.S.P. uses the method for Chiniofon after heating the assay sample first with 1 ml of 95 per cent ethanol and then 15 ml of sodium hydroxide solution until the ethanol has been expelled, 1 ml O-OSN silver nitrate 0-009924 g. 

Chiniofon Sodium using an amount of sample equivalent to about OT g of the diethanolamine salt. The weight per ml is determined and the percentage w/v calculated. The iodine content can be checked either by the flask-combustion method (p. 800) or the Stepanow method (p. 310). The total solids are almost exactly double the iodine content. 

This is ethyl 10-(/>-iodophenyl)undecanoate. It can be assayed by the flask-combustion method using 30 mg, 1 ml 0-02N thiosulphate = 0 001388 g or the alkali-fusion method given under Chiniofon Sodium. 1 ml 0 1 N thiosulphate == 0-006939 g. In the U.S.P. the iodine is assayed as under Injection of Iodised Oil using 300 mg. 

The iodine content can also be determined as for Chiniofon Sodium, using 0 05 g of substance and titrating with 0-05N sodium thiosulphate, 1 ml 0 05N — 0 002059 g, or by the flask-combustion technique using 16 mg of substance, 1 ml 0-02N thiosulphate = 0-0008235 g of pheniodol. 

Injection of Propyliodone, B.P. A sterile, 50 per cent w/v suspension of propyliodone in water for injection containing suitable dispersing agents. It is assayed as under Chiniofon Sodium using 0-1 g of the well-mixed injection and titrating with 0-05N sodium thiosulphate. 

Certain halogen derivatives of 8-hydroxyquinoline have a record of therapeutic efficacy in the treatment of cutaneous fungus infections and also of amebic dysentery. Among these are 5-chloro-7-iodo-8-quinolinol [130-26-7] (iodochlorhydroxyquin, Vioform), 5,7-diiodo-8-hydroxyquinoline [83-73-8] (diiodohydroxyquin), and sodium 7-iodo-8-hydroxyquinoline-5-sulfonate [885-04-1] (chiniofon) (196—198). 

Mixture of 80% of 8-hydroxy-7-iodoquinoline-5-sulfonic acid and 20% sodium bicarbonate chiniofon quiniofon ... 

Chiniofon, N,F., is a mixture of 7-iodo-8-hydroxyquinoline-5-sulphonic acid, its sodium salt, and sodium bicarbonate. 

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